Tadalafil instruction price analogs

Features

• Ingredients: Tadalafil 20 mg
• Time of action: Up to 36 hours
• Onset of action: After 25-45 minutes
• Active ingredient: Tadalafil (Tadalafil)
• Daily dosage: 20 mg
• Application: Suitable for daily use
• Alcohol compatibility: Compatible

Tadalafil

The drug Tadalafil, intended for the treatment of erectile dysfunction, is a crystalline substance, solid, practically insoluble in water. It is a selective inhibitor of the enzyme specific phosphodiesterase type 5, which in the smooth muscles of the corpus cavernosum of the penis destroys cyclic guanosine monophosphate, which promotes the expansion of the walls of blood vessels and the actual occurrence of an erection. Only positive reviews were received on the action of the remedy, and the side effects against the background of the effectiveness of the remedy were called insignificant. The main component of Tadalafil is a chemical of the same name and a small number of additional auxiliary components.

Action

In a healthy man, with sexual arousal and / or sexual stimulation, there is a significant blood flow through the arterial vessels of the penis, which ensures an increase in pressure in the cavernous (cavernous) bodies. With erectile dysfunction, the normal process of blood filling is accompanied by problems. The most common of these is the too rapid destruction of cGMP by the enzyme PDE-5, which causes relaxation of the walls of blood vessels, a decrease in the density of the penis and a decrease in erection. Tadalafil can be indicated for this problem, since its action is aimed at inhibiting PDE-5. Among the disorders in which the drug can become an effective remedy are psycho-emotional disorders, problems with hormonal levels and metabolism. According to its clinical action, the drug is a vasodilator (vasodilator). It has an inhibitory effect on the work of the PDE-5 enzyme, therefore, cGMP does not disintegrate for a long time, it acts for a longer time, which leads to the development of a stable erection. A prerequisite for the effective action of Tadalafil is the presence of natural sexual arousal and / or sexual stimulation. This is due to the fact that cGMP, which is necessary for vasodilation, is produced under the influence of NO (nitric oxide), which in turn is released upon excitement. In the process of sexual arousal, the spinal cord and the brain exchange a number of impulses, a command is given to release nitric oxide, its action leads to the active production of cGMP and erection due to the expansion of the walls of blood vessels. Only after this does Tadalafil come into effect, enhancing and prolonging the action of the enzyme, making the erection stable and long-lasting. In other words, thanks to the drug, the natural process of arousal is intensified and prolonged, but not artificially created.

Application

Studies have shown that the maximum effect is achieved when Tadalafil is taken orally with a small amount of water, about a quarter of an hour before the planned sexual intercourse. In the next 36 hours after taking the pill, attempts to commit sexual intercourse will be successful. The time to achieve the desired effect is calculated in each case individually, while it is important to remember that it is unacceptable to abuse the drug: the normal average dosage is no more than 20 mg when taken no more than once a day. The norm is such for men, both middle and elderly (over 65 years old), dosage adjustment is not required. The use of the drug in combination with such drugs as Itraconazole, Ketoconazole, Nefazodone, Ritonavir, Saquinavir or Erythromycin is allowed in a dosage of 10 mg no more than once every three days. Also, Tadalafil is used with caution when taking other drugs from the category of PDE-5 inhibitors. It is not allowed to combine the remedy with analogs also designed to combat the manifestations of erectile dysfunction. Rapid absorption of the drug and all components after administration was noted.

Contraindications

The use of the drug is categorically not indicated for women and children under the age of 18. The drug is contraindicated in case of individual sensitivity, intolerance or allergy to the drug itself or its components, as well as when taking alpha-blockers (Afluzosin, Ditamin, Prazosin, Tropafen, Phenoxybenzamine) and drugs containing nitrates (Molsidomin, Nitroglycerin), Vazotropycin ... Tadalafil should be used with caution in men with diagnosed diseases of the cardiovascular system, such as myocardial infarction, heart failure (above class II), angina pectoris, arterial hypotension and heart rhythm disturbances, stroke.With hereditary degenerative diseases of the retina, severe liver failure, predisposition to anatomical deformity of the penis and priapism, the drug can be taken only after consultation with a specialist.

What to fear

With different frequency of manifestation when taking Tadalafil, the following side effects are possible:

• headaches, dizziness
• problems with nasal congestion
• painful myalgic sensations
• pain in the eyes, swelling of the eyelids with reddening of the conjunctiva
• dyspepsia symptoms
• hot flashes

In case of an overdose of the drug, a slight increase in side effects may occur, which is treated during standard maintenance therapy. Symptoms appeared in 5-15% of men taking the drug. As practice shows, they develop during the first days after administration, pass on their own within 48 hours. Despite the fact that the described unpleasant sensations in some cases accompany an erection and to some extent worsen the experience of intercourse, many men called the side effects an acceptable evil.