Men's Health
Men's Health - Drugs

Drugs - Viagra. How to use Viagra. Side effects of Viagra. Symptoms of an overdose of Viagra.


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Nosological classification (ICD-10): F52.2 Lack of genital response
The pharmacological action of the drug Viagra:
Active substance (INN), sildenafil citrate (Sildenafil citrate)
Use of the drug Viagra: Erectile dysfunction.
Side effects of the drug Viagra: hypersensitivity, nitrate therapy.

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Restrictions on the use of the drug Viagra: anatomical deformity of the penis (angulation, cavernous fibrosis, Peyronie's disease), diseases, predisposing to the development of priapism (multiple myeloma, sickle cell anemia, leukemia), increased bleeding tendency, acute gastric ulcer and duodenal colon, hereditary retinitis pigmentosa, liver dysfunction, including cirrhosis, severe renal insufficiency (Cl creatinine less than 30 mL / min), severe hypertension (blood pressure above 170/110 mm Hg), and hypotension (blood pressure below 90/50 mm Hg), anamnestic indications ported in the previous 6 months myocardial infarction or stroke, a life-threatening arrhythmia, heart failure, unstable angina, concomitant use of drugs that inhibit CYP3A4.


Side effects of the drug Viagra: The side effects of the drug Viagra, taken with the selection of a dose observed in placebo-controlled trials and marked at ? 2% of patients taking Viagra, with a frequency of more than placebo (in brackets% incidence in the placebo group).

From the nervous system and sensory organs: headache 16% (4%), dizziness 2% (1%), flushing 10% (1%), visual disturbances (changes in color perception, increased sensitivity to light, blurred vision) thirty%).


From the respiratory system: nasal congestion 4% (2%). From the digestive tract: dyspepsia 7% (2%), diarrhea, 3% (1%). With the genitourinary system: urinary tract infections 3% (2%). For the skin rash 2% (1%).

Other side effects of the drug Viagra, to meet with a comparable frequency (2%) in the group treated with Viagra and a placebo: respiratory tract infection, back pain, flu-like symptoms, arthralgia.

In studies with a fixed dose dyspepsia (17%) and blurred vision (11%) were more frequent when taking sildenafil 100 mg compared with lower doses. When using doses higher than recommended, we observed similar side effects, but with greater frequency.


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Side effects of the drug Viagra, observed in placebo-controlled trials and occur with a frequency of less than 2% (communication with sildenafil is not clear). From the nervous system and sensory organs: fatigue, dizziness, headache, hypertension, ataxia, tremor, neuralgia, weakening of reflexes, paresthesia, hypoesthesia, syncope, depression, sleep disorders (insomnia / drowsiness), conjunctivitis, photophobia, hemorrhages in the eyeball, mydriasis, cataract, xerophthalmia, pain in the eyeballs and ears, tinnitus, deafness. Cardio-vascular system and blood (blood, hemostasis): hypotension, orthostatic hypotension, tachycardia, palpitations, myocardial ischemia, angina pectoris, cardiomyopathy, heart failure, ECG changes, including AV-block, cardiac arrest, cerebral thrombosis, anemia, leukopenia.

From the respiratory system: pharyngitis, sinusitis, laryngitis, bronchitis, dyspnea, increase in the number of sputum, increased cough, asthma.

From the digestive tract: glossitis, gingivitis, stomatitis, dry mouth, dysphagia, esophagitis, nausea, gastritis, gastroenteritis, colitis, rectal bleeding, changes in biochemical parameters of liver. From a metabolism: thirst, hypernatremia, gout, hyperuricemia, labile diabetes, hyper- and hypoglycemia.

With the genitourinary system: nocturia, frequent urination, cystitis, urinary incontinence, ejaculation disorder, anorgasmia, swelling of the genitals, gynecomastia.


From the musculoskeletal system: arthritis, arthrosis, ossalgia, myalgia, myasthenia gravis, tendon rupture, tenosynovitis, synovitis. For the skin: urticaria, herpes simplex, pruritus, skin ulceration, contact dermatitis, exfoliative dermatitis. Other side effects of the drug Viagra: peripheral edema, including swelling of the face, pain syndromes, including pain in the abdomen and chest, accidental falls, injuries and bruises, sweating, chills, photosensitivity, shock, and allergic reactions. Viagra drug interactions with other drugs: A single dose of antacid (magnesium hydroxide / aluminum hydroxide) simultaneously with Viagra does not affect the bioavailability. Enhances the hypotensive effect of nitrates (simultaneous reception contraindicated) and the antiplatelet effect of sodium nitroprusside. At the same time taking the drug Viagra with acetylsalicylic acid (150 mg) did not increase bleeding time. Inhibitors CYR3A4 (cimetidine, ketoconazole, itraconazole, erythromycin, etc.) Increase in the plasma concentration of sildenafil (in particular cimetidine 800 mg - 56%, when taking sildenafil, 50 mg) and reduce its excretion. In single dose of 100 mg of Viagra on the background of the equilibrium concentration of erythromycin (receiving 500 mg twice daily for 5 days) AUC sildenafil increased by 182%, on the background of the equilibrium concentration of saquinavir (1200 mg three times a day) Cmax of sildenafil increased by 140% , AUC - 210%. A single dose of 100 mg of the drug Viagra on the background of the equilibrium concentration of ritonavir - a potent inhibitor of cytochrome P450 (400 mg, 2 times a day), leads to 4-fold (300%) increase Cmax and 11-fold (1000%) increase AUC sildenafil .


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Sildenafil has no effect on the pharmacokinetics of ritonavir and saquinavir. Inhibitors of CYP2C9 (tolbutamide, warfarin), CYP2D6 (selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazides and thiazide diuretics, loop and potassium-sparing diuretics, ACE inhibitors, calcium antagonists, beta-blockers and inducers of cytochrome P450 (rifampicin, barbiturates) do not have effect on the pharmacokinetics of sildenafil. It is assumed that while taking the drug Viagra with inducers of CYP3A4 (rifampicin and others.), Its plasma concentration will be reduced. AUC of the active metabolite of sildenafil is increased by 62% at the reception loop and potassium-sparing diuretics and 102% - when receiving nonspecific beta-blockers (the clinical significance of these effects is not defined). There were no signs of interaction with amlodipine (5 and 10 mg): average additional lowering of blood pressure in the supine position (Sad 8 mmHg, DBP 7 mm Hg) was comparable to that at the reception of sildenafil to healthy volunteers. Not enhances the hypotensive effect of alcohol in healthy volunteers with the blood alcohol concentration to 80 mg / dL. Overdose of the drug Viagra Symptoms: in studies in healthy volunteers at a single dose to 800 mg of sildenafil was observed increased severity of side effects.


Treatment of an overdose of a drug Viagra: symptomatic. Dialysis is ineffective because of the high degree of binding of sildenafil and its metabolite plasma proteins. How to use Viagra drug and dose: Inside, approximately 1 hour before sexual intercourse, 50 mg. Given the efficacy and tolerability of the dose can be increased to 100 mg or decreased to 25 mg. The maximum daily dose of 100 mg, the maximum recommended frequency of administration - one time per day. Precautions for the use of the drug Viagra: Before taking to diagnose erectile dysfunction, determining its possible causes and the selection of adequate treatment is necessary to compile a complete medical history and conduct a thorough urological and general clinical examination, especially in patients with underlying cardiovascular disease, which increased sexual activity is undesirable (for example, in severe forms of coronary artery disease and hypertension). In patients older than 65 years, with liver and severe renal insufficiency (Cl creatinine less than 30 ml / min), and while the application of inhibitors of cytochrome P450 3A4 (erythromycin, ketoconazole, itraconazole, saquinavir et al.), The initial dose is 25 mg. At the same time taking ritonavir maximum single dose should not exceed 25 mg within 48 hours.

There are post-marketing reports of rare cases, an erection lasting longer than 4 hours and priapism that require immediate medical attention to prevent damage to the tissues of the penis and irreversible erectile dysfunction.

Safety of the drug while taking Viagra with other drugs to treat erectile dysfunction has not been studied, concomitant use is not recommended. Do not indicated for use in infants, children and women.

Healthy Man Viagra Pills - Impotence. Side effects of Viagra, Levitra, Cialis

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Treating impotence drug Tribestan.
Side effects of Viagra, Levitra, Cialis.
Symptomatic treatment of impotence.

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Impotence treatment is aimed at eliminating the underlying disease, which was the cause of impotence. But it is not always possible to achieve complete recovery from impotence in such cases, resorted to the symptomatic treatment of impotence.


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Viagra. Positive opportunities Viagra: dreams and hopes come true and impotent men with erectile dysfunction all over the world! Trying to drug developers to create a cure for cores has led to the fact that Viagra has become a revolutionary tool in reducing the potency and erectile dysfunction impotence.


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Pills Viagra discord with alcohol and drugs (it is better to die of orgasm than an overdose), overdose is Wigry has already cost the lives of many pensioners, survivors it remains incurable impotent. Among other side effects: mental disorders (increased aggressiveness), death (registered more than 1000 cases), paralysis.

Vardenafil or Levitra - CPMP was approved in autumn 2002, will go on sale in 2003. Positive opportunities Levitra:
After the use of the drug 77% of the men were able to make normal sexual intercourse (compared to Viagra after 55%). Levitra works faster than Viagra side effects significantly less. Moreover, to achieve the desired result sufficiently small doses.
Side effects of the drug Levitra: Headache, flushing, rhinitis and dyspepsia.

The positive possibilities of the drug Cialis: Cialis increases the potency drug for more than a day. The duration of action of the drug Cialis - 36 hours after ingestion of 20 mg of the drug, versus 8-12 hours after consumption of Viagra. The negative effects of the drug Cialis: Cialis is contraindicated in people with heart failure. Side effects of the drug Cialis: Headaches and back pain, upset stomach.


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Impotence treatment - intracavernous administration of drugs The first way to treat impotence - artificial achieving an erection. Treatment of impotence, erection is achieved by injection of vasodilator drugs into the corpus cavernosum of the penis before intercourse. Such a method of treating impotence may be used no more than once per week. The main disadvantages of the treatment of impotence include: the possibility of complications and sclerosis of the cavernous tissue and painful erections.


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For 20 minutes before sexual intercourse man enters with a special device in the urethra dose of the drug, and then he comes quality erection, which lasts about an hour.


Impotence treatment - therapy local negative pressure For an erection male sexual organ is to put in a special tank, which creates a negative pressure. This method of treatment of impotence is quite simple, but the effect of it is stored for long. Impotence treatment - drug therapy


Drug therapy is aimed at: Impotence treatment - improving the overall tone Treatment of impotence - the saturation of the body with vitamins and trace elements Treatment of impotence - a small increase in the intensity of the blood flow of the penis These drugs not only help to improve erections, but also have a beneficial effect on the entire body.


Impotence treatment - vascular surgery on the penis If impotence is caused by pathological changes in blood vessels, it is carried out an operation whose principal objective - to enhance the inflow of arterial blood to the penis and make it difficult venous flow.


Impotence treatment - intracavernous falloprotezirovanie If more than one method of treatment for impotence does not help, then resorted to intracavernous falloprotezirovanie. With falloprotezom erection is caused more "natural" than with other techniques.

Men's Health - Testosterone

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The hormone testosterone, the level and rate of testosterone in the body. The analysis of testosterone. Testosterone plays a decisive role in the social life of men. Men with higher levels of testosterone, not only are more successful in social life, but they also need and higher levels of testosterone to maintain their activity, and therefore the concept of "individual rate of testosterone" His Majesty Testosterone.


Testosterone is a hormone called winners. The level of testosterone in the blood After their victory in the fight, after the successful solution of some problems. The feeling of satisfaction and a festive mood, covering the winner, slows down the formation of stress hormones, to achieve victory. There is increased allocation of testosterone. It is evident that stress hormones and testosterone are the opposite leads to the physiological reduction in testosterone may be a significant exercise. Men sportsmen hypothalamus produces less of the hormone that stimulates the formation of gonadotropins, including LH, responsible for the synthesis of testosterone in the testicles. The problem is the overloading resulting from intensive sports training that appears entails a significant reduction in blood levels of testosterone. If a person feels the need and love, and in the race, will notice that his interest in sex dies, he may himself make the choice that he wants. Constant stress and mental overload and lead to a decrease in testosterone levels.


The hormone testosterone, the level and rate of testosterone in the body.


The immediate physiological regulators of male sexual activity is the androgens - male sex hormones, which, although in varying degrees, but stimulate all elements of his sex life - libido, erection, ejaculation and orgasm. Experience to date clinical and experimental data allows to identify some patterns that contribute to the definition of the place of male sex hormones in the regulation of male potency and sex drive.


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The hormone testosterone. The main male sex hormone is testosterone. The latter can metabolize in two directions. Functional differences of testosterone and dihydrotestosterone 5-detected even in the embryonic period. Depending on the level of testosterone bodies are the seminal vesicles, vas deference, epididymis; 5 digidrosteron stimulates the growth of the prostate, testis, urethra, penis. Under the influence of androgens - male sex hormones in the embryonic period occurs sexual differentiation of the brain of male type, which determines the type of post-pubertal sexual behavior and the secretion of gonadotropins. Changing the content of androgens - male sex hormones in the body can be due to physiological causes (daily fluctuations, seasonal, age changes) or dysfunction of Leydig cells and therefore a decrease in the concentration of testosterone or a disorder of its metabolism in obesity, liver disease, and others. The level of androgens - male sex hormones in the blood of healthy young men varies considerably throughout the day. The maximum concentration of testosterone in the early hours of the morning and one in the morning to a minimum. Similar undergoes fluctuations and the level of free, bound to proteins of blood testosterone, which determines the motivation and other forms of sexual desire. Nocturnal emissions, morning and nocturnal erections confirm the dependence of the various elements of male potency and sexual desire the level of testosterone. The association of increasing potency and strengthen erections in the night and early morning hours in the young men disappear in old age, when the circadian rhythm of testosterone levels are very weak. Not only the level of androgens - male sex hormones defines sexual activity, but also the intensity of sexual activity reflected in the content of androgens. Immediately after the intercourse levels of testosterone in the blood increases; posteyakulyatornaya hyperandrogenism and is accompanied by an increase in the concentration of epididymal sperm. Young men even after watching erotic or sexual films testosterone levels increased, on the contrary, a long abstinence leads to a decrease in testosterone levels.


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Thus, the relationship between sexual activity and endocrine function of the testis is mutual. In the application of anti-androgens in men consistently observed loss of sexual potency, then the ability to get an erection and then to orgasm. The inhibitory effect of androgens on the libido and male potency is confirmed by experimental data. Factors cause reduced potency in men is a progesterone and its derivatives. These data indicate the stimulating effect of testosterone to increase potency and libido in men. However, with the constant low level of testosterone sex life difficult or impossible. The lower limit of the level of testosterone, which is still evident in the sexual activity of men is 2.0-4.5 nmol / L. Therefore, within the normal physiological range testosterone correlation between the frequency of sexual intercourse, erotic interests and content of testosterone in the blood is not clearly fixed. Consequently, for the individual and the physiological fluctuations of testosterone levels from 12.5 to 40.6 nmol / L are significant differences in the nature of sexual behavior in men is not observed; only during the transition of these boundaries can be fixed sexual dysfunction. Low testosterone levels, and decreased potency usually recorded simultaneously. The duration of the erectile dysfunction depends on the level of testosterone in the blood. Thus, the relationship of potency and erection forces on the level of testosterone in the blood is clearly observed only outside its optimum level. An analysis of data from clinical studies suggests that testosterone stimulates the motivational component of sexual behavior - libido and erection. Testosterone increases libido by increasing the sensitivity of the hypothalamic centers of sexual desire, tactile receptors of the external genitalia. Characteristically, women libido is also stimulated by testosterone. The relationship between testosterone levels and erectile function is particularly pronounced at night penile swelling and restoration of erection under the influence of androgens - male sex hormones in impotent men. Even in the absence of clinical signs of androgen deficiency secondary erectile dysfunction accompanied by a decrease in testosterone levels. Dependence enhance erection and orgasm strength of testosterone seen in the different age groups of healthy men and men who have sexual dysfunction. Not only libido, erection and increase with increase in testosterone levels.


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The basic amount (about 98%) in the male testosterone circulates in the plasma protein-bound form with albumin and globulin, sex hormone binding SHBG (sex steroid svyazyvayushim globulin - SHBG, testosterone-estradiol-binding globulin svyazyvayushim TEBG). Only about 2% of testosterone is in the unbound, free form. The biologically active (bio-available in English literature - bioavailable) are free and albumin-bound fraction of testosterone. According to the Massachusetts study of older men, the level of bioavailable testosterone begins to decline since 30-35 years at a rate of about 2-3% per year, and total - from 50-55 years to 0.8-1.6% per year, similar changes obtained in other studies. So, at age 80 the average obshego testosterone plasma is approximately 60% of the average of his 20 years of age, and free - only 20%. Such a difference in the levels of the fractions can be explained by the age increase SHBG content (about 1.6% per year). However, despite the drop in obshego testosterone concentration in some cases, does not exceed the lower limit of normal (less than 12 nmol / l). For this reason, and adopted the phrase "partial androgenodefitsit" showing that the absolute hypogonadism, but there is a significant reduction in hormone levels compared with those of the same patient at a younger age.