How seroquel affects potency

Quetiapine (Seroquel, Ketilept, Lakvel)

Root 29 May 2012

Perfect soul 29 May 2012

Question to the male half of the community. How does seroquel affect potency and libido.

I, although the female half, can safely answer that it does not affect in any way)

Root 29 May 2012

I, although the female half, can safely answer that it does not affect in any way)

Perfect soul. I would be infinitely happy if this is true. Thank you.

Pirat-007 Jun 12, 2012

Perfect soul Jun 12, 2012

Completely turned off libido at a dose of 200mg

Libido from 200mg, it can't be, it's self-hypnosis. seroquel does not affect libido at all.

Deltel Jun 22, 2012

Deltel Jun 25, 2012

The doctor immediately prescribed me a dosage of 400 mg / day. In general, I came home and took one tablet in the evening. By the way, I took one pill the next morning.

I want to clarify i.e. The doctor prescribed me 400 mg Ketilept in 2 divided doses. i.e. I took one tablet of Ketilept 200 mg in the evening, and another one the next morning.

Seroquel is an effective and well tolerated atypical antipsychotic

Antipsychotic drugs are the mainstay of treatment for patients with schizophrenia. These drugs cause many side effects, the most serious of which are extrapyramidal symptoms. This article provides an overview of published data from preclinical and clinical studies of Seroquel TM , a new atypical antipsychotic agent. Preclinical studies have predicted a low risk of developing extrapyramidal symptoms, and this issue has been specifically studied in clinical trials in patients with exacerbations of moderate to severe schizophrenia. In fact, the incidence of extrapyramidal symptoms with Seroquel does not differ from their frequency with placebo over the entire dose range. Seroquel is generally well tolerated with no more side effects than standard antipsychotics. In terms of efficacy in the treatment of schizophrenia, Seroquel proved to be no less effective than the previous antipsychotics haloperidol and chlorpromazine. Thus, Seroquel offers the physician significant advantages over standard antipsychotics. (Int J Psych Clin Pract 1997; 1: 231-239)

Key words: atypical antipsychotic, Seroquel TM (quetiapine), schizophrenia, extrapyramidal symptoms, clozapine

INTRODUCTION

Antipsychotics reduce hallucinations, manic episodes, and psychomotor agitation in patients with schizophrenia and other psychoses. These remedies differ more in the side effects they cause than in their therapeutic effect, in which they are very similar. Approximately 75% of patients experience complete resolution of symptoms or a significant reduction 1,2 , while the remaining patients show resistance to treatment.

Standard antipsychotics cause a range of side effects, the most serious of which are extrapyramidal symptoms (EPS) 3,4. EPS are thought to increase the risk of depression 5 and non-compliance, and may also contribute to the rate of suicide attempts. 6,7 Among patients with schizophrenia, non-compliance with treatment followed by relapse was found to be associated with EPS in 60% of cases. 8-10 Although EPS are a major group of adverse events with standard antipsychotics, it is important not to underestimate the additional burden on patients with schizophrenia of other adverse events, including the consequences of hyperprolactinemia, sexual dysfunction, anticholinergic effects, cardiovascular disorders, seizures, and weight gain.< /p>

Thus, many physicians would agree that there is a need for new antipsychotics for two reasons: 1. there is a significant number of patients (albeit a minority) who are resistant to treatment, for whom an effective antipsychotic agent would be very useful; and 2. those patients who respond to treatment (they are the majority) would be happy to take newer drugs that cause fewer side effects. Following clozapine with its unique properties, a new generation of atypical antipsychotics has begun to be developed that may offer significant advantages over standard antipsychotics. This article provides a review of data on a new and promising atypical antipsychotic, quetiapine (Seroquel, ICI 204,626). It first briefly highlights the preclinical work that first drew attention to the potential of this chemical, then focuses on its clinical efficacy and tolerability, properties most important to psychiatrists awaiting new and better drugs for the treatment of schizophrenia.

NON-CLINICAL STUDIES

The search for new drugs to treat schizophrenia has been driven largely by the dopamine hypothesis, which is based on the observation that standard antipsychotics share a dopamine antagonistic property. Potential antipsychotics have been principally identified by their ability to combat the effects of the dopamine agonists amphetamine and apomorphine. However, it turned out that drugs selected only by this criterion often cause EPS, since they all have the ability to block postsynaptic D2 receptors. The only exception to this was clozapine, a drug that was withdrawn from use in the 1970s because of its tendency to cause agranulocytosis. Although clozapine has recently been rehabilitated because it was found to be clinically effective in the treatment of drug-resistant schizophrenia 11 , a condition for obtaining a license was the requirement for weekly white blood monitoring, which severely limited its acceptability. This prompted an intensive search for new atypical antipsychotics that would be similar to clozapine in their activity in animal models and in their ability to bind receptors.

It is possible that Seroquel is one of these compounds. Preclinical studies of Seroquel included an extensive set of tests in a wide variety of animal models (see reviews by Goldstein 12 and Casley 13) that provided evidence that Seroquel had a preclinical profile different from that of standard antipsychotics, but closely resembling that of clozapine, which allows us to hope that its clinical properties may also be similar.

Affinity for neuroreceptors

Similar to clozapine, Seroquel binds a range of receptors, including dopamine D1 and D2 receptors, serotonin 5-HT2A and 5-HT1A receptors, histamine and adrenergic alpha1 and alpha2 receptors. Again similar to clozapine, but unlike standard antipsychotics, Seroquel has a relatively weak affinity for dopamine D2 receptors and a much greater affinity for serotonin 5-HT2 receptors.

Antipsychotics

Seroquel is active in a number of behavioral tests commonly used to predict antipsychotic efficacy, including the conditioned avoidance test in monkeys and the normalization of apomorphine-provoked behavior in monkeys, mice, and cats (for a full review, see Goldstein 12). Although modeling negative symptoms in animals is an extremely difficult task, the effects of amphetamine on the social behavior of Java monkeys regarding negative symptoms appeared to have some degree of predictable validity. Seroquel has been able to suppress these phenomena, which raises hope that it may have improved clinical efficacy in combating the negative symptoms of schizophrenia.

EPS animal models

The selectivity of Seroquel to the limbic system is seen in the suppression of amphetamine-induced inhibition of cell firing at lower doses in limbic A10 dopamine cells than in motor A9 dopamine cells. These phenomena predict the relative absence of EPS in humans.

Most of the drugs that cause EPS in humans also cause catalepsy in rats at doses expected to be antipsychotically effective. However, in the case of Seroquel, the dose causing the antipsychotic effect, i.e. 5-20mg/kg is much less than the 80mg/kg dose required for the cataleptic equivalent induced by the 4mg/kg dose of haloperidol 15.

Antipsychotics produce distinct expression patterns for early gene products such as c-fos in the forebrain. Haloperidol and other standard antipsychotics, which are prone to developing EPS, are associated with c-fos expression in both the limbic and motor regions, while c-fos expression with clozapine is limited to the limbic regions. Seroquel behaves similarly to clozapine in this model, which may predict a low propensity to develop EPS in clinical practice. 16

Perhaps the most compelling virtue of Seroquel is that it has a minimal tendency to develop dystonia in both haloperidol-sensitive and never-treated monkeys. This is thought to hold promise for a reduced propensity to develop EPS and, with long-term use, tardive dyskinesia in humans. 14

Overall, these results suggest that, in clinical practice, Seroquel plus clozapine will be less likely to cause EPS than standard antipsychotics.

Effects on serum prolactin

Unlike standard antipsychotics such as haloperidol, Seroquel causes only small and short-term increases in serum prolactin levels in rodents after administration. In this respect, Seroquel is also similar to clozapine, which produces little or no stimulation of prolactin. 17

Preclinical data on Seroquel, especially its similarity to the atypical antipsychotic clozapine, gives strong confidence that it will be effective in treating both positive and negative symptoms of schizophrenia and be relatively free from EPS. The remaining sections of this review are devoted to the analysis of how these expectations were justified in practice.

CLINICAL PERFORMANCE

To date, more than 3,000 patients have been treated with Seroquel. A summary of completed, controlled clinical trials is shown in Table 1. The primary inclusion criterion for all studies was a diagnosis of DSM-III-R exacerbation of chronic or subchronic schizophrenia. Patients treated in these studies were in a state of exacerbation of the disease, usually with a long history of the disease, repeated hospitalizations and prior experience with antipsychotics. Thus, they probably represented patients commonly encountered in clinical practice.

Table 1. Clinical studies on the use of Seroquel in the treatment of schizophrenia. All studies lasted 6 weeks.

Antidepressants and potency: do drugs cause erection to fall?

Antidepressants are drugs that have a pronounced psychotropic effect on the human body. Medications are recommended to be used to eliminate depression, depression, and they affect the concentration of neurotransmitters.

The disorder of the mental state of a man leads to lethargy, apathy, bad mood and a negative emotional background. Unreasonable fear and anxiety, nervous tension appear.

That is why the doctor prescribes antidepressants to the patient, which help to normalize the patient's well-being, eliminate sleep disturbance, restore appetite and restore normal mood.

Antidepressants and potency, are these two concepts compatible? How do drugs affect the potency of men, and is it worth drinking them at all? Are they able to increase potency, or vice versa, provoke its decrease?

How do antidepressants affect the male body?

The modern pharmacological industry presents a huge list of drugs that help eliminate depressive syndrome and mental disorders. In the vast majority of cases, any drug from this category has its own negative reactions.

As a rule, nausea, vomiting, sleep disturbance, allergic reactions with skin manifestations are most often observed. In other words, a "traditional set" of adverse reactions is revealed.

Other drugs disrupt the functionality of the gastrointestinal and digestive tract, provoke constipation or diarrhea, and can lead to the development of gastritis or a chronic peptic ulcer.

If antidepressants are prescribed to a man at an older age, then the doctor should inform the patient that such drugs significantly increase the risk of strokes and heart attacks.

And yet, do antidepressants affect or not affect male strength? As an example, we can cite several drugs with their mechanism of action on the genital area:

• The drug Remeron has such a side effect as weight gain and increased drowsiness, which negatively affects the quality of erection.
• Trittico can lead to long-lasting erections in young men, which can only be cured by surgery.
• Wellbutrin has an interesting mechanism of action. Reviews of doctors indicate that this drug reduces cravings for cigarettes, and can temporarily increase potency in men.

In 2012, extensive clinical studies were carried out, the purpose of which was to identify the effect of medications, in particular antidepressants, on the male body. For the study, several volunteers were selected who had been taking antidepressants for a long time.

After a full-scale examination of men, the final conclusion was made that, regardless of the name of the drug, the age of men and their comorbidities, any psychotropic agent negatively affects male strength.

How to take antidepressants?

In a number of situations, the appointment of antidepressants is really justified, and despite the likelihood of developing a huge number of side effects, they are still recommended by the attending physician.

It is worth noting that an antidepressant that increases potency is only a temporary phenomenon, which over time will lead to a completely opposite result, erectile dysfunction is not ruled out, and later the diagnosis of impotence.

Definitely, each man decides individually whether to drink or not to drink psychotropic drugs. However, if there is no choice, it is necessary to minimize the development of problems with potency.

Some men testify that long-term use of antidepressants has led to the fact that the erection disappears during sex, the penis becomes sluggish and lifeless. And this is true, since the drugs contain potent substances that thus affect the male body.

The main recommendations for the use of antidepressants to help minimize the harmful effects of drugs on the male body:

In the process of therapy, as soon as a man notices manifestations of a negative nature on the part of his body, you must immediately notify the doctor. Perhaps another drug will be recommended, or the dosage of the drug will be revised.

Depression is a complex diagnosis that is no less difficult to treat. Unfortunately, sometimes the only way to normalize mental health is antidepressants, respectively, and all their side effects.

The potency spray M-16, which includes natural herbal ingredients, will be sprayed directly on the penis, as a result of which a high-quality erection and a strong penis are observed.

Men's problems from pills, when to sound the alarm?

Definitely, nothing will change from the first use of medications in a man's body. However, the insidiousness of drugs lies in the fact that they have a negative effect on the nerve endings, which in turn leads to a decrease in male strength.

Patient reviews show that on about 5-7 days of admission, a poor erection is already observed, sexual activity and libido decrease.

In a number of situations, it is impossible to refuse the use of antidepressants, and stimulating pills for erection cannot be combined with them at all, since they contain chemical and synthetic compounds, which in their symbiosis can even lead to a worsening of the situation.

It is necessary to pay attention to natural remedies that will help restore male strength and self-confidence. For example, Peruvian Maca for erection enhancement is the recommended remedy in this case, it works quickly, and most importantly, it is safe.

It is also worth noting that if a decrease in sexual strength is detected, it is necessary to visit a doctor so that he can correct psychotropic treatment, or prescribe another antidepressant to minimize the negative impact on the male body.

Despite the huge selection of antidepressants, all of them to some extent adversely affect the potency and erection of men, so whether or not to take the medicine must be decided on an individual basis, comparing the likely harm and potential benefit.