Fluoroquinolones 4th generation for the treatment of prostatitis

List of fluoroquinolones broad-spectrum antibiotics

Why do we need antibiotics in our time, even a schoolboy knows. But the phrase "wide range" sometimes raises questions from patients. Why wide? Perhaps there will be less harm from an antibiotic with a narrow spectrum?

Bacteria are very ancient, most often unicellular, non-nuclear microorganisms living in soil, water, humans and animals. "Good" bifidobacteria and lactobacilli live in the human body, these bacteria form the human microflora.

Along with them, there are other microorganisms, they are called opportunistic pathogens. With illness and stress, the immune system fails and these bacteria become completely unfriendly. And of course, various microbes that cause diseases enter the body.

Scientists divided bacteria into two groups, Gram-positive (Gram +) and Gram-negative (Gram -). Corynebacteria, staphylococci, listeria, streptococci, enterococci, clostridia belong to the gram-positive group of bacteria. The causative agents of this group, as a rule, are the cause of diseases of the ear, eyes, bronchi, lungs, nasopharynx, etc.

Gram-negative bacteria negatively affect the intestines and the genitourinary system. These pathogens include E. coli, Moraxella, Salmonella, Klebsiella, Shigella, etc.

Based on this bacterial separation, antibiotic therapy is prescribed to treat diseases caused by certain pathogens. If the disease is "standard" or there is a result of bacterial culture, the doctor prescribes an antibiotic that will cope with pathogens belonging to one of the groups. When there is no time for analysis and the doctor doubts the affiliation of the pathogen, then antibiotics with a wider spectrum of action are prescribed for treatment. These antibiotics are bactericidal against a large number of pathogens.

Such antibiotics are divided into groups. One of them is a group of fluoroquinolones.

Quinolones and fluoroquinolones

Preparations of the quinolone class have been used in medical practice since the beginning of the 60s of the last century. Quinolones are divided into non-fluorinated quinolones and fluoroquinolones.

• Non-fluorinated quinolones have an antibacterial effect mainly on the gram-negative group of bacteria.
• Fluoroquinolones have a much broader spectrum of action. In addition to influencing a number of Gram-bacteria, fluoroquinolones also successfully fight Gram-positive bacteria. Antibiotics fluoroquinolones show a high bactericidal effect, thanks to which medical preparations for topical use (drops, ointments) have been developed, which are used in the treatment of diseases of the ears and eyes.-

Four generations of drugs

• 1st generation quinolones are called non-fluorinated quinolones. It consists of oxolinic, nalidixic and pipemidic acids. For example, based on nalidixic acid, uroantiseptic preparations Negram and Nevigramon are produced. These antibiotics are bactericidal against Salmonella, Klebsiella, Shigella, but do not cope well with anaerobic bacteria and Gram + bacteria.
• The second generation of fluoroquinolone drugs consists of the following antibiotics: norfloxacin, lomefloxacin, ofloxacin, pefloxacin, and ciprofloxacin. With the introduction of fluorine atoms into quinolone molecules, the latter became known as fluoroquinolones. Fluoroquinolones of the 2nd generation fight well with a large number of Gram-cocci and rods (Shigella, Salmonella, gonococci, etc.). With gram-positive rods (listeria, corynebacteria, etc.), legionella, staphylococcus, etc. Ciprofloxacin, lomefloxacin and ofloxacin suppress the increase in mycobacteria that cause tuberculosis, but at the same time show little activity in the fight against pneumococci, chlamydia, mycoplasmas and anaerobic bacteria.

Names of drugs containing 2nd generation fluoroquinolones

3rd generation fluoroquinolones

3rd generation fluoroquinolones are also called respiratory fluoroquinolones. These antibiotics have the same wide spectrum of influence as the previous generation of fluoroquinolones, and also surpass them in the fight against pneumococci, chlamydia, mycoplasmas and other pathogens of respiratory infections. Due to this, the 3rd generation of fluoroquinolone drugs is often used to treat diseases of the respiratory system.

Names of drugs containing 3rd generation fluoroquinolones

4th generation

The 4th generation of fluoroquinolone drugs includes the following most well-known drugs: moxifloxacin, gemifloxacin, gatifloxacin.

Medications containing 4th generation fluoroquinolones-

Fluoroquinolones 4th generation for the treatment of prostatitis

For many years you have been unsuccessfully struggling with PROSTATITIS and POTENTITY?

Head of the Institute: "You'll be amazed at how easy prostatitis can be cured by taking it every day.

It cannot be said that there is any universal antibiotic for prostatitis, since any antimicrobial therapy must take into account the individual sensitivity of bacteria in each specific case. The choice of drug depends on the type of pathogen, as well as on its susceptibility or resistance to antibiotics. The dosage, as well as the duration of the course, is selected by the doctor, taking into account the severity of the process (acute or chronic), drugs with a wide spectrum of action are most often used. Usually, the course prescribed by the andrologist lasts 1-2 months, while antibiotic treatment is complex, along with other drugs and procedures, namely:

• non-steroidal anti-inflammatory drugs;
• drugs that normalize blood circulation;
• vitamin therapy;
• immunostimulating drugs;
• sedatives and antidepressants;
• phytotherapy.

Massage of the gland, as well as manual massage with thermal microwave therapy, are indicated only after the risk of tuberculosis infection has been excluded, since thermal exposure and massage cause a sharp exacerbation of the tuberculosis process.

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Depending on the type of pathogen, based on its sensitivity to certain drugs, different antibiotics are chosen:

• Tetracycline is used for all known pathogens, except for gonococci, Proteus and Pseudomonas;
• penicillin is not used against chlamydia, mycoplasma and ureaplasma;
• cephalosporin is indicated in the presence of gonococci, enterobacteria, Klebsiella, Proteus and Escherichia coli;
• macrolide is especially effective against ureaplasma, mycoplasma, chlamydia, gonococci, enterobacteria and E. coli;
• Fluoroquinolone is recommended for E. coli.

In addition to the above pathogenic microorganisms, fungal agents may be involved in the inflammatory process of the prostate or urinary system.

To date, the most effective drugs for prostatitis are fluoroquinolones, since these antibiotics have phototoxicity and neurotoxicity. Fluoroquinolones are included in the therapeutic anti-tuberculosis complex, so if the patient is waiting for the results of seeding for tuberculosis, this drug cannot be used.

The use of tetracyclines has recently declined markedly. Now, doxycycline is mainly used, which patients tolerate relatively more easily than other tetracycline antibiotics.

From the penicillin group, a drug based on Clavoalan acid and Amoxicillin is now widely used, which is characterized by a stronger antibacterial effect.

Cephalosporin preparations are intended for intramuscular injection. These include Suprax, Cefotaxime, Kefadim, Cefspan, Klaforan, Ceftriaxone and others.

Macrolides are not often used, due to the lack of studies that would confirm the feasibility of their use in the treatment of prostatitis, however, they are practically non-toxic and very active in the fight against a number of bacteria, especially mycoplasmas and chlamydia.

Few of the antibiotics tend to accumulate in high concentrations in the tissues of the prostate, which should be considered when choosing a drug, since the level of drug concentration in the prostate gland is of great importance in the treatment of prostatitis. Therefore, the use of aminoglycosides, macrolides, fluoroquinolones is most preferable. Including when diagnosing acute bacterial prostatitis, it is desirable to prescribe several (more often than two) antibacterial drugs at the same time to get rid of acute inflammation more quickly.

Scheme of treatment of prostatitis with antibiotics

The course of antibiotic therapy can last 6-12 weeks, while the drugs can be used alternately. It is also allowed to use several drugs at once.

If prostatitis causes a fever, intense severe pain in a patient, then they resort to intravenous administration of antibiotics. The duration of their reception can be 4-6 weeks. Several medications may be recommended by the doctor. If, after a course of antibiotics, the patient's health did not improve, then most likely the disease was not caused by a bacterial infection.

It is strictly forbidden to stop antibiotic treatment on your own even in cases of a clear improvement in the patient's condition, since prostatitis, being a very insidious disease, is characterized by a tendency to relapse.

How to choose antibiotics for chronic, acute or bacterial prostatitis?

Treatment of inflammation in the prostate gland is carried out using groups of drugs. In the presence of a bacterial infection, antibiotics are prescribed for prostatitis. They eliminate the influence of harmful microorganisms and inflammation, accelerate the healing process. In order for the therapy to be effective, it is important to determine with the doctor which antibiotic for prostatitis in men is more effective. This can be done based on the results of the tests.

How to choose a drug?

The use of antibiotics for prostatitis is indicated when a bacterial form of the disease is detected. An infectious lesion can be eliminated by determining the type of pathogenic microflora and its sensitivity to antibacterial agents.

Drugs for treatment

Treatment of prostatitis with antibiotics is carried out with a preliminary analysis of the secretion of the prostate gland. Until this moment, any drugs, except for anti-inflammatory, painkillers and decongestants, are prohibited. Otherwise, negative side effects may appear, and the therapy will not give a positive result.

The patient needs to know that there is no universal answer to the question of how to treat inflammation in the prostate gland. Therefore, an examination must be carried out. Then, at home, you can carry out antibiotic therapy.

An antibiotic is prescribed by a urologist after an examination

Antibiotics in tablets

Antibiotics for prostatitis in men in the form of tablets can be with various active ingredients in the composition. The list of drugs used for bacterial prostatitis includes many items.

Josamycin

Prostatitis can be treated with antibiotics using macrolides. These include Josamycin, which has a bacteriostatic effect. It concentrates in the inflammatory focus and eliminates the influence of harmful microorganisms.

Antibiotic Astellas Wilprafen (Josamycin)

It has almost no side effects. Some patients report loss of interest in food, nausea and heartburn.

Roxithromycin

Roxithromycin is a semi-synthetic macrolide antibiotic. At a reduced dosage, it has a bacteriostatic effect. If the treatment regimen for prostatitis is prescribed using high doses, then the drug eliminates the pathogenic microflora.

Roxithromycin, 10 tab.

The drug is contraindicated in patients suffering from liver failure and allergic to the active substance.

Doxycycline

At home, prostatitis can be treated with Doxycycline. It fights mycoplasmas and chlamydia. Tetracycline antibiotic inhibits bacterial protein synthesis.

Doxycycline (Doxycyclinum) is a broad-spectrum tetracycline antibiotic

The absorption of the active component is carried out instantly in the organs of the gastrointestinal tract. If you take a pill with a meal, the process slows down slightly.

Cefotaxime

Cefotaxime

You can take Cefotaxime for prostatitis and incipient adenoma, which can eliminate the effect:

• anaerobes;
• gram-negative microorganisms;
• gram-positive bacteria.

Before taking the drug, the patient needs to make sure that there is no allergic reaction to cephalosporins and penicillins. The drug can lead to Quincke's edema.

Ciprofloxacin 250mg

Ciprofloxacin

In chronic prostatitis, the antibiotic Ciprofloxacin is prescribed. It is commercially available in the form of tablets.

Ciprofloxacin (Ciprofloxacinum) is prescribed for chronic prostatitis

Ciprofloxacin should be taken before meals. It is worth remembering that the drug is not prescribed for:

• stab;
• an allergic reaction to the active substance;
• treatment of chronic diseases of other organs with medicines.

Ceftriaxone

The third generation cephalosporin is Ceftriaxone. It eliminates anaerobic and gram-negative bacteria, successfully fights gram-positive microflora. The agent helps to suppress the synthesis of cell membranes.

Ceftriaxone vial

It is recommended to stop taking the drug for men who suffer from an allergic reaction to:

Caution is taken during the treatment of chronic prostatitis with an antibiotic for hepatic and renal pathologies, enteritis and colitis.

Ceftriaxone injections

During the treatment it is necessary to exclude the use of alcoholic beverages. Otherwise, various disorders may appear in the body.

Azithromycin

Effective antibiotics for the treatment of prostatitis - drugs based on azithromycin. They are used in the treatment of infectious diseases of various body systems.

Azithromycin (Azithromycin) - a semi-synthetic broad-spectrum antibiotic

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The drug can be used both in the acute and chronic stages of the disease. It is prescribed after a large number of leukocytes and harmful microorganisms are detected in the analyzes.

Amoxicillin

A good semi-synthetic antibiotic used in the treatment of inflammation in the prostate gland is Amoxicillin. It has an enhanced bactericidal effect, so the symptoms are eliminated after a few days after using the drug.

Amoxicillin tablets

Lomefloxacin

An antimicrobial drug with a bactericidal effect is Lomefloxacin of the fluoroquinolone group. It is a vital and essential drug.

Lomefloxacin for prostatitis

The drug has various contraindications for use. It should be taken with caution when:

• cerebral atherosclerosis;
• epilepsy;
• impaired functioning of the central nervous system;
• hypokalemia.

In the presence of cirrhosis of the liver, treatment adjustment is not required. This rule applies to patients who do not have kidney problems.

Levofloxacin

Levofloxacin has a wide spectrum of action. It is used in the treatment of prostatitis provoked by various pathogenic microorganisms.

Levofloxacin - an antibacterial drug of the fluoroquinolone group

This product may impair kidney function. Therefore, people suffering from kidney pathologies should take pills only under the supervision of a doctor.

Ofloxacin

The antibiotic Ofloxacin easily penetrates the prostate tissue. Due to this, it quickly acts on the focus of inflammation and harmful microorganisms.

Despite its high efficiency, Ofloxacin can provoke the appearance of adverse reactions. Among them are:

• dizziness;
• slowness;
• impaired consciousness;
• drowsiness;
• nausea and vomiting.

Ofloxacin Darnitsa

Overdose is treated symptomatically.

There are some contraindications to taking the remedy. These include deficiency of glucose-6-phosphate dehydrogenases, epilepsy, reduced convulsive threshold, high sensitivity to the active substance Ofloxacin. It is worth being careful in patients who have atherosclerosis of blood vessels in the brain, circulatory disorders, kidney pathologies, damage to the central nervous system of an organic nature.

Antibiotic suppositories

In addition to the means of general exposure, patients may be prescribed suppositories for prostatitis with antibiotics. They are effective remedies due to local effects on the focus of inflammation.

Antibiotic suppositories are an effective local remedy

Proctosedyl

Proctosedyl suppositories are prescribed for the treatment of acute and chronic stages of the disease. They consist of six active ingredients, including an antibacterial component. Due to this drug:

• eliminates itching of the genitals;
• eliminates the inflammatory process;
• reduces pain;
• combats pathogenic microflora;
• accelerates tissue repair.

Using suppositories

Suppositories with Erythromycin

For the treatment of prostatitis, suppositories with the antibiotic Erythromycin are used. They quickly eliminate the influence of pathogenic microflora. The drug does not cause side effects.

Erythromycin suppositories can sometimes cause side effects

It rarely causes side effects. Nausea, dizziness, and hearing loss may occasionally occur. All symptoms disappear quickly after the suppositories are cancelled.

Levomycetin suppositories

In the treatment of acute and chronic prostatitis, Levomycetin suppositories are prescribed. In the case of pronounced symptoms, the use of suppositories is carried out three times a day.

Prostatitis treatment with rectal suppositories

Due to the impact of chloramphenicol, cellular proteins of bacteria are destroyed. Therefore, the tool is able to fight any microorganisms, except for Mycobacterium tuberculosis, coccal, and infections resistant to methicillin.

Synthomycin

Many doctors in the treatment of inflammation in the prostate gland prescribe suppositories with Synthomycin. The antibiotic acts on cell membranes, making it impossible for the division and reproduction of pathogenic microflora. In this case, not only the inflammatory process is eliminated, but the likelihood of further development of the infection is also excluded.

The drug is prescribed for diseases caused by activity:

• shigella;
• escherichia;
• salmonella;
• staphylococcus;
• Streptococcus;
• protea;
• treponemes.

Antibiotics should be selected exclusively by a doctor. Self-medication can lead to various complications.

Fluoroquinolones and macrolides

Moderator: dvd-rw

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Fluoroquinolones and macrolides

1 Message 112233332211 " Wed Apr 07, 2010 3:59 pm

Can they be combined? To guarantee the result.

P.S. I apologize if the topic has already been, I did not find it.

2 Posted by Norbekovec " Wed Apr 07, 2010 4:16 pm

3 Post by bedolaga " Wed Apr 07, 2010 4:47 pm

4 Posted by igorusha " Wed Apr 07, 2010 6:51 pm

5 Post by dvd-rw " Wed Apr 07, 2010 8:41 pm

But your teachers think differently!

In the treatment of inflammatory processes of the urogenital tract caused by Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis, antibacterial drugs are used that affect the protein and DNA synthesis of the pathogen. Tetracyclines (oxytetracycline, rondomycin, doxycycline), macrolides (erythromycin, roxithromycin, clarithromycin, azithromycin) and fluoroquinolones (ciprofloxacin, lomefloxacin, pefloxacin) have these properties. macrolides are not always effective enough. The active use of antibacterial agents in the treatment of various inflammatory diseases has led to an increase in the number of resistant microorganisms, which makes it relevant to study the phenomenon of resistance, as well as methods for determining resistance in clinical populations. ---..

6 Message 112233332211 " Wed Apr 07, 2010 9:50 pm

Some past contradictions, everyone has their own opinion and everyone substantiates it.

7 Posted by igorusha " Wed Apr 07, 2010 9:51 pm

But your teachers think differently!