What is an alpha blocker for prostatitis for?

Alpha blockers: drugs for the treatment of prostatitis

Alpha blockers are drugs that can slow down nerve impulses passing through the adrenergic synapse. Their action is based on a temporary blocking of adrenoreceptors (alpha-1 and alpha-2). This property is used in cardiology (to reduce blood pressure in blood vessels) and urology.

The use of drugs such as alpha-blockers for prostatitis allows you to restore urination, impaired due to inflammation of the prostate.

What are alpha blockers for?

The nervous system is directly related to the work of human organs and muscle control. When a person is healthy, this mechanism does not fail. However, with prostatitis, inflammatory processes adversely affect the functioning of the nervous system. First of all, this can be seen from the work of receptors that provoke spasms of the urethra and smooth muscles of the bladder. Because of this, a man cannot go to the toilet normally, and urination disorders are one of the main signs of inflammation of the prostate.

Alpha-blockers are used as medical aids in the treatment of inflammation of the prostate gland. They act in a targeted manner, helping to relax the smooth muscle tissue of both the prostate and the bladder neck with an increase in the outflow of urine portions. At the same time, there is a significant reduction in the pronounced symptoms of prostate enlargement.

Alpha blockers are introduced into the drug regimen during treatment to increase the effectiveness of the main drugs used. Therefore, in medical therapy they are referred to as the second line of active drugs, when necessary:

• reduce internal pressure in the urethra;
• reduce the tone of the smooth muscles of the prostate and bladder neck;
• increase the tone of a weakened bladder.

Alpha blockers for prostate pathology are designed to alleviate the course of the disease, but not cure it. This is purely symptomatic therapy. After applying them, the following effects are observed:

• normalization of urine outflow;
• relaxation of smooth muscles with a decrease in pain;
• return of sexual desire;
• liquidation of blood stasis in the small pelvis;
• reduction of manifestations of benign organ hyperplasia.

Classification of alpha blockers

These medications are divided into:

• non-selective drugs that block both alpha-1 and alpha-2 adrenoreceptors (phentolamine, phenoxybenzamine);
• short-acting selective agents that block only alpha-1 receptors (prazosin);
• long-acting selective agents capable of blocking only alpha-1 receptors (terazosin, doxazosin, alfuzosin);
• Uroselective drugs (tamsulosin).

Selective agents do not require prior preparation and only in rare cases cause mild side effects. Despite significant advantages, this species has one property that men of reproductive age must take into account.

It has been established that under the influence of the active components of the drug, retrograde ejaculation develops, in which the release of seminal fluid occurs not into the urethra, but into the bladder. Let us consider in more detail all the drugs used to treat prostate pathologies.

However, most experts agree that selective drugs are somewhat better than non-selective ones, since the latter have a stronger effect on the bladder and nervous system.

Tamsulosin

One of the most commonly used drugs. It has a selective effect on receptors in the male gland, bladder neck and prostatic urethra. In addition to the main properties of all blockers, it is able to reduce the inflammatory response and obstruction in the organ.

Produced in the form of capsules of 30 pcs. package, coated with a dosage of the main substance - 0.4 mg. For the treatment of prostatitis, take 1 capsule 1 time per day during breakfast with 150 ml of water or milk.

The course of treatment is 2-3 months, depending on the instructions of the attending physician. The first effect occurs after 2 weeks of using the medicine.

• dizziness;
• tachycardia, orthostatic reactions;
• loss of appetite, nausea, vomiting, constipation;
• premature or retrograde ejaculation;
• itching, rash on the skin.

• hypersensitivity to the components of the product;
• tendency to hypotension with loss of consciousness;
• Severe liver failure.

At the moment, Tamsulosin is the most popular representative of its group among doctors.

Doxazosin

Another selective alpha-1 receptor antagonist.It has a similar effect as the previous drug. The main difference and the reason for the significantly less popularity of this tool is the need for titration during use.

Produced in tablets 1, 2, 4, 8 mg, 30 pieces per pack. The average daily dose is 4 mg. Use 1 tablet 1 time per day with meals. The first week is prescribed a dosage of 1 mg, after 7 days - 2 mg, and so on up to the average norm of 4 mg. The course of therapy is 3 months.

• drowsiness, headache, asthenia (weakness);
• rhinitis, formation of peripheral edema;
• nausea, vomiting, diarrhea;
• very rarely - urinary incontinence.

Contraindications Allergy to the components of the drug.

It is worth saying that alpha-blockers in the acute course of the disease show a poor result. This is due to the duration of the onset of the first effects. When using Doxazosin, their effect occurs only after 14 days, which is unforgivably long during acute manifestations.

Alfuzosin

The only popular and widely used non-selective alpha receptor blocker. It has all the same properties as its counterparts, but has a number of disadvantages, due to which it is less often used in urology.

It's basically an effect on all the alpha receptors in the body. As a result, the smooth muscles of the vessels (hypotension), the intestines (constipation) and the respiratory tract relax.

Produced in the form of tablets of 5 mg. The daily dose is 7.5-10 mg, depending on the severity of the disease and the prescription of the attending physician. You need to take 1/2 tablet (2.5 mg) 3 times a day with meals, drinking 200 ml of water. The course of therapy is 2-3 months. You can not combine this medicine with other drugs from the same group. In this case, the effect of both is leveled.

• weakness, drowsiness, tinnitus, dizziness;
• tachycardia, orthostatic hypotension, exacerbation of angina pectoris;
• dry mouth, nausea, vomiting, constipation;
• itching and rash on the skin.

• allergy to drug components;
• renal or liver failure;
• Hypotension in anamnesis.

The drug is non-selective and requires a gradual increase in daily dosage. The amount of active substance during the first dose should not exceed 1 mg. Gradually increase the dose to 10 mg during maintenance therapy and up to 20 mg during the treatment of inflammation of the prostate gland. The first results are felt 14 days after the start of the course. It takes 1-1.5 months to achieve a sustainable clinical effect.

Terazosin is available in the form of tablets. It is recommended to drink them in the evening before going to bed. This will reduce the likelihood of Side effects.

• asthenia;
• impaired vision;
• swelling of the mucous membranes of the respiratory organs;
• sexual dysfunction.

• allergy to drug components;
• renal or liver failure;
• pathologies of the cardiovascular system.

Conclusion

Medicines of this group are very effective for relieving the main symptoms of prostate inflammation. However, it must be understood that they can only serve as an addition to the main course of treatment.

Due to their long-term action, such drugs are much more effective in chronic prostatitis than in the acute phase of the disease. The intake of these funds, in order to avoid the development of serious adverse reactions, should be prescribed only by the attending physician.

Useful video

Use of alpha blockers for prostatitis: description of drugs

The following drugs are commonly used to treat inflammation of the prostate: anti-inflammatory drugs, alpha-blockers and antibacterial drugs. Ibuprofen, paracetamol and diclofenac are used to reduce the inflammatory response in the prostate.

Using alpha-blockers for prostatitis

With prostatitis in men, the pressure inside the bladder increases due to the narrowing of the prostatic part of the urethra. The rate of urination also decreases, and the neck of the bladder is not fully opened. Intraprostatic reflux is a consequence of impaired smooth muscle function. Restore the tone of smooth muscles drugs from the group of alpha-blockers.

Antibiotics will be used only if an infectious nature of the disease is suspected, which is confirmed by the results of a smear from the urethra. Fluoroquinolones, cephalosporins are used more often than others, aminoglycosides and protected penicillins are slightly less common.

What is it

Alpha-blockers are drugs that do not allow adrenomimetic substances to come into contact with their specific receptors. Thus, they have a vasodilating effect on peripheral arterioles and precapillaries.In the treatment of prostatitis, their main effect is used - improving urodynamics.

There are two groups of these drugs: selective and non-selective alpha-blockers. Selective, which block alpha1-adrenergic receptors - tamsulosin, prozazin, daxosazin. Yohimbine is a selective alpha2-blocker. But tropodifen, proroxan and phentolamine are non-selective alpha1- and alpha2-blockers and act on both types of receptors simultaneously. In turn, selective drugs differ in the duration of their action.

How they help and what they do

When using alpha-blockers, the blood supply to peripheral tissues improves. This happens due to a decrease in vascular resistance, expansion of small veins. It also reduces the load on the heart and slightly drops blood pressure. Thanks to the action of alpha-blockers, the patient can get rid of frequent painful trips to the toilet, incomplete emptying of the bladder and a weak stream.

Indications and contraindications

Impotence in men is the main reason for the use of alpha2-blockers.

These drugs are contraindicated in case of allergic reactions to the drug, unstable pressure, severe liver or kidney disease.

Alpha1,2-blockers are indicated for:

• Vascular encephalopathy.
• Vascular migraine.
• Neurogenic bladder.
• Prostate adenoma.
• Angiopathies in diabetes.
• Raynaud's disease

Contraindications for their use:

• Bradycardia
• Blood pressure reduction
• Recent myocardial infarction
• Acute bleeding
• Pregnancy and lactation in women
• Allergy to a drug or ingredient

Alpha1-blockers are prescribed to patients with:

• Heart disease with stenosis of one of the valves.
• Pregnancy and lactation.
• Allergic reactions to the drug.
• Severe kidney or liver failure.
• Persistent arterial hypotension.

Description of drugs

Alfuzosin

The drug has a selective effect only on alpha1-adrenergic receptors. It relaxes the smooth muscles that are located in the area of the urethra, the sphincter of the bladder, thereby improving the outflow of urine.

Alfuzosin is available as 5 and 10 mg tablets. It is taken half a tablet 2-3 times a day. It is mainly used in the treatment of manifestations of prostate adenoma. For the treatment of women, the drug is not used.

Side effects of alfuzosin: exacerbation of coronary heart disease, hypotension, increased heart rate, weakness, dizziness, headache, dyspeptic disorders, dry mouth, rash, flushing of the skin and swelling.

Tamsulosin

It is also a selective alpha1-adrenergic blocker. It has a weak effect on blood pressure. It acts on smooth muscle cells of the prostate, bladder, urethra. Tamsulosin reduces irritation and obstruction of the urethra, promotes the outflow of urine. It is used for benign prostatic hyperplasia, and the effect of taking appears from 3 weeks.

Side effects: hypotension, tachycardia, sleep disturbance, headaches, diarrhea, nausea, decreased libido, skin itching, allergic edema. With an overdose of the drug, a sharp drop in pressure can be observed. The drug is produced in tablets of 0.4 mg.

Doxazosin

The drug is from the same group, but differs in the features of its action. The effect is most pronounced in the vessels of the kidneys and skin. It has a moderate antihypertensive effect. Reduces the level of cholesterol and low density lipoproteins in the blood. Relaxes the smooth muscles of the bladder neck and prostate gland. It is used for prostate adenoma, hypertension, and sometimes for CHF and pheochromocytoma.

Side effects of doxazosin: dizziness, edema, arrhythmias, weakness, irritability, dyspepsia, impaired blood supply to the brain.

The drug relaxes the walls of blood vessels and reduces peripheral resistance. It is mainly used to quickly lower blood pressure. It is used orally and intravenously at a dose of 25 mg.

Of the side reactions, weakness, tachycardia, dyspeptic disorders, allergic reactions are possible.

The drug belongs to dietary supplements for the treatment of impotence in men. It increases libido and improves penis erections. It is also effective in atony of the bladder. It is used 1 tablet up to 3 times a day for a course of about 1-2 months.

In case of an overdose, there may be: coordination disorders, weakness, hand tremor, nausea, vomiting, pupil dilation, increased sweating.

Before using any means, be sure to consult a doctor!

Alpha-blockers for prostatitis

4 weeks ago men's diseases 122 Views

Treatment of prostatitis is a long process. Depending on the causes of the disease, the main therapy may differ. Conventionally, all drugs are divided into two groups. The first includes painkillers, antibiotics and anti-inflammatory drugs. The second group (venotonics, immunomodulating and AAB) is additional. The most common auxiliary drugs for prostatitis are alpha-blockers.

The main role of alpha-blockers

In the treatment of prostatitis with alpha-blockers, the function of urination, impaired due to inflammation, is restored. The human nervous system has a direct connection with the work of all organs, and also takes part in muscle control. In a healthy body, there are no failures in this mechanism. But inflammatory processes in the prostate negatively affect the NS.

First of all, this is noticeable in the receptors. They cause spasms of the muscles of the bladder and urethra. As a result, it is impossible to go to the toilet normally, which is the main sign that the prostate is inflamed. AAB act directed. Thanks to them, smooth muscle tissue relaxes, and urine outflow increases.

The drugs are included in the complex treatment regimen in order to increase the effectiveness of the main drugs. They are assigned when required:

• reduce internal pressure in the urethra;
• increase bladder tone;
• reduce the tone of the bladder neck and prostate.

Alpha-blockers can only relieve the symptoms of prostate pathology, but they are unable to cure the disease. After such symptomatic therapy, the following is observed:

• urine outflow returns to normal;
• stagnation of blood stops in the small pelvis;
• sex drive is restored;
• pain syndrome decreases;
• The manifestations of BPH (benign prostatic hyperplasia) are reduced.

Classification of drugs

Medicines are divided into 4 classes:

Selective preparations do not need preparation. Side effects are mild and rare. Despite such advantages, the use of such agents should be considered for patients of reproductive age. Studies have shown that the active substances of selective drugs provoke retrograde ejaculation. As a result, the release of sperm occurs in the bladder, and not in the urethra. Despite this, most doctors are of the opinion that the use of selective agents is better than non-selective ones, because they do not affect the NS and bladder as much.

Tamsulosin and Terazosin

Tamsulosin is one of the most popular drugs used for prostate inflammation. Among its analogues are Fokusin, Omnik, and Tulosin. A medicine is prescribed for dysuria (impaired urination), prostatic hyperplasia and chronic prostatitis.

Prim tablets helps to relax the smooth muscles of the prostate and urethra. As a result, all symptoms disappear, and urination is facilitated. After 4 hours, the maximum concentration of the drug in the blood is observed. The required therapeutic dose accumulates in the body after a five-day course, the medication does not give an instant effect.

The dosage is 400 ml of the active ingredient per day, which is equal to one tablet. It must be taken with food. Dividing the capsule into parts is not allowed, as well as chewing. It must be swallowed whole and washed down with plenty of water. The duration of therapy may vary, this is determined by a specialist.

There are the following contraindications:

• intolerance to the components of the drug;
• renal failure;
• female.

Minor side effects include nausea, allergies, drowsiness, dizziness, rapid heart rate, headache. It is not recommended to combine Tamsulosin with other AABs, Furosemide. It should be borne in mind that the drug reduces concentration. Packing cost 30 pcs

Terazosin is a non-selective drug, during which it is necessary to increase the daily dose to 20 mg in the process of relieving inflammation and up to 10 mg during maintenance treatment. At the first dose, the dosage of the active ingredient in 1 mg should not be exceeded. The effect should be expected no earlier than 2 weeks, and in order to achieve sustainable results, the course should last from 1 to 1.5 months. Release form - tablets. To prevent side effects, take them before bedtime.

Among the side effects observed:

• general weakness of the body;
• throat swelling;
• failures in sexual function;
• reduced vision.

Contraindications are: diseases of the heart and blood vessels, intolerance to the components of the drug, impaired renal and liver function.Packing cost 20 pcs

Doxazosin and Alfuzosin

Doxazosin is a selective antagonist that reduces the concentration of cholesterol in the blood and promotes the expansion of peripheral vessels. The drug is less popular due to the need for titration during use. Release form - tablets of 30 pcs. On average, a dosage of 4 mg per day is prescribed, but the first week is always 1 mg, the second - 2 mg, the third - 3 mg, the fourth - 4 mg. Assigned to 1 table. in a day. It should be taken with food. The course of treatment is 3 months.

When taking the product, the following side effects may occur:

• urinary incontinence (very rare);
• headaches;
• Indigestion and nausea;
• General weakness of the body, drowsiness;
• respiratory failure and rhinitis.

Among the contraindications, only intolerance to the components of the drug

Alfuzosin release form - tablets of 5 mg and 10 mg. They are prescribed for failures in the function of urination and prostatitis. Due to the active components of the drug, the pressure of the inflamed organ on the bladder decreases and the tension in the urination channel decreases. Due to this, the flow of urine does not lend itself to resistance, and the process of urination is easier. In this case, only alpha-1 receptors in the prostate are affected, while other vessels remain unaffected.

Alfuzosin method of application: 5 mg in the evening and in the morning, it is forbidden to exceed the dose of 10 mg. The tablet should be taken with a small amount of water. The dosage for elderly men who suffer from arterial hypotension is reduced to 5 mg of the drug per day. Among the contraindications are hypersensitivity to the components of the drug, liver failure, a tendency to lower blood pressure when moving from a horizontal to a vertical position, simultaneous use of drugs of the same group, ischemia.

The drug is well tolerated, so side effects are rare. Diarrhea, dry mouth, abdominal pain, dizziness may occur. Sale in pharmacies is carried out only by prescription.

It is worth noting that alpha-blockers in urology in the acute course of the disease do not show a good result, since it takes a long time for the first effects to appear. The action of Doxazosin, for example, appears after 2 weeks, with acute manifestations this is unforgivable.