Esperal drug influence on potency

How esperal affects potency

How frequent alcohol consumption affects conception in men

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At present, it is difficult to find a man who would not drink alcohol, even in small quantities. Almost any man drinks beer, vodka or other alcoholic beverages, without thinking about the effects of alcohol on the body. For men, drinking beer or vodka is the ability to relax. Today, the market is represented by a wide variety of alcoholic beverages, ranging from light cocktails to vodka or cognac. Alcohol consumption is currently not controlled in any way. This was not the case in ancient times. Previously, laws were issued according to which women were forbidden to drink alcohol until the age of 30, that is, in childbearing age. All this was not just. There was an opinion that alcohol in a diluted or pure form affects pregnancy and the child himself.

As for men, there were no restrictions for them. Similar laws were issued in Ancient India and Rome. To date, due to the rapid development of medicine, the negative effect of alcohol on conception, pregnancy and fetal health has been proven. The effect on the male body is of the greatest importance, since a man drinks more than a woman. It should be considered in more detail how alcohol affects conception in men, its effect on spermatozoa and potency.

Action on male sex cells

In men, when exposed to alcohol, the following health disorders can be observed: damage to internal organs, neuropsychiatric disorders, decreased immunity, impaired potency and fertilization function. Everyone knows that the quality of sperm and spermatozoa suffer from alcohol. In what way does this manifest itself? It is known that for full-fledged fertilization in the body of a woman, spermatozoa must be mobile and healthy. Their total number is also of great importance.

Alcohol affects conception in men in such a way that, as a result of its systematic use, germ cells lose their mobility.

In addition to all this, their number is decreasing. Hypospermia or aspermia may occur. All this contributes to the fact that fertilization of the egg does not occur.

In more severe cases, alcohol disrupts the genetic apparatus of spermatozoa, and various genetic abnormalities and deformities may occur during the formation of a zygote and fetus. Very often mentally retarded children (with Down syndrome) are born to alcoholic parents, developmental anomalies are observed. Conception in men is a serious matter, so before planning a child, you need to give up alcohol at least 3 months before fertilization. Spermatozoa are renewed in men every 3-4 months. With toxic exposure, the motor activity of male germ cells decreases by an average of 20%.

Conceiving a child while drunk

Alcohol and conception are two incompatible things. Many will wonder how alcohol affects conception in men in a drunken state. Alcohol very quickly penetrates into the bloodstream and spreads to all cells and tissues of the body. Scientists have proven that alcohol consumption during direct fertilization prevents conception, because sex cells are among the first to be affected by alcohol. Normally, the gonads contain approximately 25% of pathological spermatozoa that are not able to fertilize the egg.

When drinking beer, vodka or any other similar drink, active spermatozoa are affected. As a result, almost all cells reduce their activity and mobility, which reduces the chances of successful conception. Alcohol acts on spermatozoa in two ways: firstly, it reduces the quality of sperm, and secondly, it reduces its production by the gonads. All this happens pretty quickly. This fact suggests that parents must be sober in order to conceive.

Alcohol and potency in men

The effect of alcohol on conception can manifest itself in a decrease in potency, which in turn will lead to the impossibility of fertilization. It has been proven that taking 100 g of alcohol per day negatively affects the central nervous system, reduces sexual desire (libido). In addition, with the defeat of some parts of the brain, the production of germ cells may suffer. For conceiving a child, it is important that sexual partners have close contact and attraction to each other.

With the constant ingestion of alcohol into the body of a man, his sexual desire decreases, interest in his partner is lost, which entails negative consequences. With the frequent use of large doses of alcohol, especially of low quality, it can have a direct toxic effect on the sex glands - the testes.Over time, complete impotence may occur, which can be very difficult to cure.

The effect of alcohol on the fetus

Exposure to alcohol is especially dangerous for an unborn child. Damaged male germ cells as a result of fertilization of the egg transfer part of the genetic apparatus damaged by the toxic effect of alcohol. In the course of laying the organs and systems of the unborn child, genetic defects, disorders in the formation of tissues and organs may appear. The most sensitive in this regard is the brain. All this can lead to congenital malformations and deformities. As a result of drunken conception, the unborn child may experience the following disorders: weight loss and a decrease in height at birth, underdevelopment of the brain, impaired mental and mental activity, anomalies in the development of individual organs and systems.

Still in the womb, the fetus may experience discomfort. In addition, very often the child's nutrition is disturbed due to vasoconstriction, in particular the umbilical cord. Particular attention should be paid to the so-called alcohol syndrome in a child during the birth period, which is characterized by functional and morphological abnormalities in the state of health.

Should I drink alcohol or not?

It is very difficult for the male body to completely give up alcohol. What to do in such a situation? The thing is that alcohol affects the body of a man not only negatively. With a small use of it, there may not be any changes in sexual function. According to experts, drinking a glass of wine a day has a positive effect on the body of a man. The problem is that not everyone loves wine. Men prefer vodka and beer. Today, there are a lot of fakes (surrogates of alcohol) on the market of alcoholic beverages, the quality of which is very low. Drinking cheap alcohol is not recommended.

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The effect of alcohol on conception is an important aspect of planning pregnancy and childbirth. There have been many scientific studies on this subject. Surveys of women were conducted, as a result of which it turned out that the majority of men who drank alcohol did not have any problems in sexual terms, while teetotalers had problems with potency. The fact is that such a positive effect is short-term and quickly disappears with the systematic intake of alcohol.

Conclusion, conclusions, recommendations

The effects of alcohol on males, whether young or old, are almost always negative. Alcohol is a toxic compound. Its dose, relatively harmless to the human body, is 20-40 g. At higher concentrations, internal organs and cells, in particular the sex glands and spermatozoa, can be affected. It is they, along with brain cells, that are most susceptible to the effects of alcohol.

In order to avoid negative impacts on sperm and the unborn fetus, planning is essential. This should be done by both men and women. In the event that a man cannot comply with dry law, then such drinks can only be consumed in small quantities.

The quality of raw materials matters. If you follow all the above rules, then you can have a full sexual life and not be afraid for the health of your own and unborn child.

Alcoholism is a serious problem of mankind. The main danger is that for the time being it seems that we ourselves control when and how much to consume alcoholic beverages. However, the further you go, the more difficult it becomes to control yourself, and in the end, it is no longer a person who controls how much to drink, but drinking begins to control a person.

How drugs work

Two types of preparations are used for coding with injections:

• Disulfiram drugs inhibit the metabolism of alcohol in the body, increase the content of the toxin acetaldehyde by almost 10 times. This toxin causes severe symptoms of poisoning. The consequences of taking even a sip of alcohol are severe nausea, vomiting, palpitations, panic, dizziness, impaired stool, shortness of breath, convulsions, headache.
• Naltrexone drugs block the endorphins responsible for the pleasure of drinking alcohol. The negative consequences of alcohol consumption remain (slowdown, hangover, etc.), but a person does not experience any euphoria and relaxation before them. It is more easily tolerated than the previous drug (there are no consequences of severe poisoning), but its effectiveness is also lower.

The task of coding with injections is to evoke negative emotional associations with the intake of alcoholic beverages, thereby removing the addiction to regular consumption. If the encoded person does not drink alcohol, then the injected drug does not manifest itself in any way.The duration of the blockade effect of injections varies - on average, it ranges from 1 to 3 years, but it is worth remembering that over time the effect becomes weaker until it disappears completely.

The disadvantage of coding an injection is that if a person breaks loose and takes too much alcohol during the period of the drug, the consequences can be so strong that they can even lead to death.

Advantages over other methods

Coding with disulfiram and naltrexone drugs can be not only in the form of injections, but also through tablets and implants. Different people in their reviews praise different ways. However, objectively, injection coding has several advantages:

• Injections are taken less frequently than tablets: tablets must be taken daily, often patients simply get tired of taking them. In addition, in the form of injections, drugs enter the bloodstream faster, so the effect occurs almost instantly. Injections are used for all forms of addiction, pills - only for initial ones.
• Injections, compared to implants (binders), create the feeling of a real treatment, so they are taken more seriously. In addition, injections are cheaper than implants.

How much does injection coding cost

The price of injection coding depends on the drug used, its concentration (duration of action), the authority of the clinic or the doctor giving the injection and monitoring its effect. Here are the approximate prices for drugs for coding for alcoholism:

Why an injection may not work

Can an injection not work? This is rare, but it happens, as the few reviews say. In one case out of a thousand, the active substances that make up the drug do not work on a person - there are no consequences of drinking alcohol after coding, nothing prevents the patient from getting drunk. There is nothing you can do about it - the reason is in the individual characteristics of the organism. There is only one way out - to look for another way to get rid of alcoholism.

The thrust may also be ineffective for a more trivial reason: blocking may not occur if a fake is entered. Unfortunately, some unscrupulous clinics, wishing to save money on drugs, inject cheap pacifiers into their patients, and charge money as for the original drug. That is why you need to carefully choose clinics, carefully reading reviews on them and studying all the necessary certificates.

Requirements for Injection Therapy

The following requirements apply:

• Coding by injection into a vein is accepted only after consultation with a specialist. You cannot prescribe a method for treating alcoholism yourself.
• The procedure is recommended to be repeated no more than 3 times in a row (due to the rather strong effect of the drugs and pronounced side effects). If even after the third injection into the vein of the coding substance, the person still returned to drinking alcohol, one should try a different way to get rid of alcoholism.
• Injections can be given provided that the patient has not taken alcohol for at least three days (ideally, the last drink of alcohol should be a week).
• The coding decision should be made by the patient. In no case should injections be forced. It won't do any good.
• When an injection is given, it is important not only not to drink alcoholic beverages, but also to refuse food and medicines that contain alcohol (even kefir and kvass can cause rejection).

You don't have to believe in absolute miracles. From one injection, a complete recovery will not occur. After all, in addition to physical traction, there is also a psychological one. Yes, injections into a vein do not allow drinking for some time, as they cause terrible consequences, but the patient’s head will still want to drink alcohol.

The inability to take a dose of alcohol can manifest itself in increased aggressiveness, apathy, depression, and various neurological disorders. Therefore, the coding course should always be combined with psychological assistance sessions, as well as the removal of toxins from the body, so that a person feels all the benefits of a clean body. Maintenance therapy reduces the chance of relapse.

For whom injections are not suitable

There are several contraindications to injection coding. This type of getting rid of alcoholism is prohibited in diseases of the cardiovascular system. The injections themselves cannot be given in acute forms of acute respiratory viral infections, pregnancy, kidney failure, cancer, diabetes. Very carefully it is necessary to carry out treatment with injections of people with mental disorders. Disulfiram and naltrexone, which are part of the coding drugs, can provoke clouding of consciousness, psychosis, and various kinds of hallucinations.

In other cases, injection coding is allowed and shows good results. In most patients, even after the completion of the coding period, a persistent aversion to alcoholic beverages remains.The main thing is that a person understands that alcohol harms him and that he should not drink anymore. Do not abuse alcohol and be healthy!

Content

Pharmacological properties of Esperal

Pharmacodynamics. Disulfiram inhibits the action of many enzymes. Inhibition of acetaldehyde dehydrogenase leads to an increase in the concentration of acetaldehyde, a metabolite of ethyl alcohol, which causes unpleasant symptoms: intense facial flushing, nausea, vomiting, discomfort, tachycardia and hypotension. Pharmacokinetics. When taken orally, disulfiram is rapidly but not completely absorbed (70-90%). It is rapidly metabolized: it turns into diethyldithiocarbamate, which is then excreted in the form of a glucuronide or transformed into diethylamine and carbon disulfide. Part of the carbon disulfide is excreted by the lungs. The remainder is metabolized and excreted in the urine.

Indications for the use of Esperal

Adjuvant therapy to prevent relapse of alcohol dependence.

Using Esperal

The drug is intended for oral use. It is recommended that adults take 1 tablet per day. The tablet should be washed down with water (1/2 cup), taken in the morning during breakfast, after refraining from drinking alcohol for at least 24 hours. The duration of the course of treatment is determined by the doctor individually.

Contraindications to the use of Esperal

Hypersensitivity to disulfiram or any component of the drug. Severe liver failure. Renal failure. Severe respiratory failure. Diabetes. Neuropsychiatric disorders. Cardiovascular diseases. Use of alcoholic beverages or medicines containing alcohol within the last 24 hours Pregnancy and lactation.

Side effects of Esperal

Side effects are caused directly by disulfiram. From the digestive tract: nausea, vomiting, stomach pain, diarrhea, metallic taste in the mouth, bad breath (halitosis), bad breath in patients with colostomy. On the part of the liver: often there is an increase in the level of transaminases; rarely - hepatitis, including fulminant and lethal forms of hepatitis. From the side of the central nervous system: polyneuritis of the lower extremities, optic neuritis. Neuropsychiatric disorders: memory loss, confusion, drowsiness and fatigue at the beginning of treatment, headache. From the skin: allergic rashes on the skin, cross-sensitivity to rubber is possible. side effects due to the combination of disulfiram-ethyl alcohol: intense flush on the face, erythema, nausea and vomiting, malaise, tachycardia and hypotension. In some cases: heart rhythm disturbance, angina attack, cardiovascular failure, myocardial infarction, respiratory depression and neurological symptoms (confusion, encephalopathy and epileptic seizures or convulsions), sudden death.

Special instructions for the use of Esperal

Esperal can be prescribed only after a comprehensive medical examination (including laboratory testing). Liver function tests, including determination of serum transaminase levels, should be performed prior to treatment with disulfiram (see CONTRAINDICATIONS section), in the future, these functional tests should be carried out at regular intervals, especially during the first 3 months of treatment. An increase in the level of transaminases in the blood serum, three times the upper limit of normal, requires immediate discontinuation of treatment without subsequent recovery. Patients should be closely monitored until normal liver function tests are established. The drug should be used with caution in patients with nickel dermatitis due to an increased risk of hepatitis. The drug should never be administered to patients without their knowledge. Since there are reports of very rare cases of fulminant hepatitis, therefore, in the event of signs of precursors (asthenia, anorexia, nausea, vomiting, abdominal pain or jaundice), you should immediately conduct a medical examination of the patient and determine the laboratory parameters of liver function tests (see. Side effects section). The patient should be informed about the risk of developing a disulfiram reaction in case of simultaneous use of the drug and alcoholic beverages, even in small quantities. Patients should be warned about the alcohol content of certain medicines (especially oral solutions), foods, and certain cosmetic products such as aftershave and eau de toilette or cologne.Unpleasant symptoms (intense flush on the face, erythema, nausea and vomiting, malaise, tachycardia and hypotension) develop within 10 minutes after drinking alcohol and last from 30 minutes to several hours. Alcohol-related reactions may occur up to 2 weeks after discontinuation of drug treatment. There are reports of more severe reactions: cardiac arrhythmias, angina attacks, cardiovascular failure, myocardial infarction, sudden death, respiratory depression and neurological symptoms (confusion, encephalopathy and epileptic seizures or convulsions). during pregnancy and breastfeeding. Animal studies have shown Esperal to be teratogenic. The teratogenic effect of the drug is enhanced by alcohol, which by its nature is already teratogenic and fetotoxic in chronic use in large quantities. There is insufficient information to assess the potential teratogenic and fetotoxic effects of the drug if administered during pregnancy. Among a limited number of patients who took the drug during pregnancy, manifestations of harmful effects were mainly observed in the case of simultaneous use of the drug with alcohol. Therefore, the use of the drug during pregnancy is not recommended. However, this is not a basis for recommending termination of pregnancy in women taking disulfiram, but rather requires caution in the use and specific antenatal monitoring of fetal development. It is not recommended to use the drug during breastfeeding. Influence on the ability to drive a car and perform work requiring increased attention. The patient must be warned that drowsiness may occur while taking the drug, so it is not recommended to drive a car and perform work that requires increased attention.

Esperal drug interactions

Not recommended combinations Alcohol: the development of a disulfiram reaction (flushing, redness, vomiting and tachycardia). Alcoholic beverages or medicines containing alcohol should be avoided. Isoniazid: violation of behavior and coordination of movements. Drugs of the 5-nitroimidazole group (metronidazole, ordinazole, secnidazole, tinidazole): Bouff es d lirantes (a type of short reactive psychosis), confusion. Phenytoin: a significant and rapid increase in the level of phenytoin in the blood plasma with toxic manifestations (due to inhibition of its metabolism). Combinations that require caution when co-administering Warfarin (with extrapolation to other oral anticoagulants): increased oral anticoagulant action and risk of bleeding (decreased liver metabolism). Tricyclic antidepressants: possible increase in alcohol intolerance reaction.

Esperal overdose, symptoms and treatment

Overdose of disulfiram alone can cause neurological effects: extrapyramidal syndrome, mental disorders (coma, confusion and encephalopathy). Treatment is symptomatic. As a result of an overdose of the combination of disulfiram-ethanol, coma or confusional syndrome, cardiovascular insufficiency, sometimes with neurological complications, may occur. Treatment is symptomatic.

Esperal storage conditions

In a dry place at room temperature, it is above 25 C.

Drugs that affect potency negatively

A man's potency is vulnerable: it decreases during an exacerbation of chronic diseases, depression, and emotional upheavals. Doctors note that even with mild violations of the functions of the heart, kidneys, liver and other vital organs, libido and erection deteriorate. After undergoing treatment and recovering, a person usually returns to the previous active sexual form, however, there are drugs that affect potency negatively.

A man may not suspect that the usual pills for high blood pressure or a sedative become a cause of grief about a failed sexual intercourse. Only by visiting a doctor, a person learns that, it turns out, it was the drugs that negatively affected male strength. In this article, we will find out which drugs inhibit sexual function.

Groups of drugs that depress potency

First of all, these are most drugs for hypertension - propranolol, pindolol, clonidine and their analogues. Benzohexonium, which causes a decrease in blood pressure, is a popular drug for hypertensive patients, but after taking it, it is more likely that erection and ejaculation will suffer. At the appointment with the attending physician, it is useful to ask how the prescribed medication works on sexual activity, for example, elanapril or captopril do not affect libido and erection.

The antihypertensive drugs clonidine and methyldopa are also dangerous from the standpoint of maintaining sexual desire, especially the latter. Clinical studies have shown that when taking methyldopa, problems with erection, libido and ejaculation occur in 80% of subjects. Clonidine, on the other hand, negatively affects the potency of every fourth person.

Hormonal medications, such as ranitidine or cimetidine, provoke increased production of the female hormone prolactin, which inhibits the production of the male hormone - testosterone. They can be replaced by a new drug - famotidine, which has similar properties, but retains male sexual function.

Almost all antipsychotics suppress libido, except for haloperidol - this drug can, on the contrary, cause an increase in sexual desire. Tricyclic antidepressants affect erection in two ways: on the one hand, they weaken the sensations of sex, on the other hand, they stop bouts of depression, due to which the hitherto weakened desire increases.

Tranquilizers have a bad effect on erection. True, when hand tremors and headaches appear simultaneously with sexual arousal, such medications will improve the situation.

Sedatives from the barbiturate group, such as phenazepam and corvalol, reduce potency in 30% of men. The same applies to drugs based on bromine.

Men suffering from edema often take diuretics - a diuretic. This group of medicines affects potency selectively: the drug triampur, for example, can increase sexual activity in one man, and decrease it in another. The danger is spironolactone when used for more than three months; in addition to sexual weakness, it causes gynecomastia.

By the way, if the diuretic is taken simultaneously with antihypertensive drugs - like octadine, reserpine and other rauwolfia preparations, the likelihood of sexual weakness increases three times. When taking this combination, desire is reduced and erection is disturbed, ejaculation is difficult.

Antihistamine drugs - diphenhydramine or tavegil, leading to drowsiness and decreased concentration, suppress the desire and ability to have sex.

A few more drugs that suppress sexual function:

• drugs for the treatment of parkinsonism,
• MAO inhibitors,
• diet pills,
• anticancer,
• anti-tuberculosis,
• sex hormones.

It is worth mentioning separately about hormone therapy: both female hormones (estrogens) and male hormones introduced into the body harm erections. The first - because they suppress the synthesis of androgens (male hormones), the second - because the body stops producing its own.

So, during the treatment of certain ailments, libido in men decreases both because of the disease itself and under the influence of drug therapy. Therefore, you should consult with your doctor about the possible temporary suppression of sexual manifestations. However, you must be aware that after the end of treatment, as a rule, potency is restored.

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