Viagra Soft

Features

• Ingredients: Sildenafil 100 mg
• Time of action: up to 4 hours
• Onset of action: 15-25 minutes
• Active ingredient: Sildenafil (Sildenafil)
• Daily dosage: 100 mg
• Application: Suitable for daily use
• Alcohol compatibility: Compatible

Description of the drug Viagra Soft

Description: Viagra Soft is an improved form of regular Viagra, due to the fact that Viagra Soft dissolves under the tongue, it became possible to use it with alcohol and fatty foods. Method of application: Viagra begins to act 15 minutes after ingestion and lasts at least 4 hours. Most patients can take Viagra daily.

The main active ingredient is sildenafil, which facilitates the entry of blood into the vessels of the penis. Within 4-5 hours, your erekial function will be restored, while the drug will not cause an erection if you do not feel sexual arousal. The tablets can be taken regularly, but not more often than once a day. Do not take the drug after 65 years, in case of serious liver and kidney disorders, problems with the cardiovascular system, leukemia or existing abnormal changes in the shape of the penis. We offer only original products that have passed all clinical trials and have proven not only their effectiveness, but also safety. The drug does not accumulate in the body, so you should not be afraid of getting used to the pills. Many men are interested in how much Viagra Soft costs. The cost of the drug in pharmacies and online stores can differ significantly, not to mention the fact that the price of the world-famous analogue - Viagra, is several times higher. The price of Viagra Soft in our pharmacy is more than affordable. The Soft option is a profitable and optimal solution that will allow you to forget about problems with potency. For every full-fledged man, rich and unrestricted sexual relations are an essential element of life. Through sexual intercourse, one gets pleasure and contentment. The quality of sexual life determines a harmonious and long-lasting relationship between spouses and partners. People equate sexual relations with self-confidence, recognition of his victories. An honorable place among the drugs that help return the pleasure of intimacy and treat complications in erectile function is occupied by analog tablets Viagra Soft. Viagra Soft is a topical remedy that restores Erectile dysfunction in men. The substance of the main action is sildenafil, which most effectively and safely affects erectile functioning. For Viagra Soft to start functioning, you need sexual desire and arousal. The principle of operation of the remedy is based on an increase in blood flow to the reproductive organ, which activates a natural erection. Panacea Viagra Soft affects mainly the natural processes of sexual arousal.

The mechanism of action of Viagra Soft

When taken orally, the pill begins to function after 20 minutes. Due to the individual characteristics of any person, the product begins to function no longer than 40 minutes. The process lasts from 4 to 6 hours. It is recommended to drink the tablets with plain water. Manufacturers advise taking the drug before meals, on an unfulfilled stomach. In this way, he will act instantly. Viagra Soft should be taken in case of sexual intercourse. It is contraindicated to use the drug in order to strengthen an erection more than 1 tablet per day. Viagra Soft activates localized blood flow into the musculature of manhood. The medication does not contribute to an increase in sexual desire and libido, and also has nothing to do with drugs that have an aphrodisiac effect. The drug is recommended for males who suffer from erectile dysfunction. Sources of malaise can be a variety of reasons. For example, the destruction of the blood capillaries and receptors of the male organ. Viagra Soft for a certain period of time activates male strength for the period of intimate relationship and causes a rise in strength, but does not cure impotence.

Characteristics of Viagra Soft

The exact name is Viagra Soft, and in international pharmacology - Sildenafil. The pharmacology of the drug is expressed as a type V phosphodiesterase inhibitor. The drug Viagra Soft is produced in the form of tablets. They have a blue tint and are convex and diamond-shaped. The edges of the tablets are smooth and rounded. Absorbing pills, active substances penetrate into the blood through the inner surface of the oral cavity. Due to the rapid dissolution, the substances have an effect in a short time and effectively. On the front side of the package there is an engraved inscription "Pfitzer", in the opposite place - VGR 25, VGR 50, VGR 100.The package of the product can contain from 10 tablets to 100, their number depends on the size of the blister. Generic tablets have a pleasant, moderately sweet taste, so their use is comparable to the resorption of lozenges or dragees. The form of release of pills and their use gives the impression of candy, and not a serious medication that fights against sexual dysfunctions. This phenomenon has a powerful psychological effect.

Components of the drug

The main element of the composition is sildenafil citrate. In tablets, it is contained in the following proportion: 25 ml, 50 ml, 100 ml. Minor substances are represented as calcium hydrogen phosphate, magnesium stearate, MCC, croscarmellose sodium. The surface shell consists of the following substances: lactose, hypromellose, titanium dioxide, triacetin and aluminum varnish from the food additive E132 or indigo carmine. If the tablets have a bluish tint, then they contain vanillin flavor and vitamin biotin. They are contained in the preparation in a small dose - from 0.75 to 3.0 mcg. The product contains additional substances that can enhance the effective result of sildenafil.

When is the drug allowed

Viagra Soft exists to cure physiological, psychological and heterogeneous disorders of erectile function, mild impotence in men, as well as diseases - pulmonary hypertension. The remedy is effective only when there is sexual libido and desire. The medication is characterized by an increase in the erection of the male organ and prolongation of the pleasure from intimacy. It is recommended to consume the drug in a concentration of 50 ml. You need to use the drug one hour before the start of sexual intercourse. Given the effective properties of the drug, the concentration may increase or decrease. The effectiveness of Viagra Soft begins with a dose of 25 mg. The permitted concentration limit is 100 mg. Men in years and people with disorders of the functioning of the kidneys and liver can use the remedy without fear.

Who should not take pills?

Overdose or misuse of the daily concentration can cause adverse effects. Viagra Soft has a specific list of contraindications. Negative manifestations occur sporadically or in isolated cases. The use of pills is not advised for persons who have heart and kidney diseases, cirrhosis of the liver, cardiac arrhythmias, deformity of the penis, as well as for persons with individual intolerance to the components and high / low blood pressure. The contained nitric oxide can have negative effects on metabolic processes. As a result, Viagra Soft enhances the negative effects of nitrate substances. For this reason, the use of the drug is contraindicated for people using drugs that contain substances such as nitrate compounds or nitric oxide compounds. Also, the use of Viagra Soft is partially not recommended for men over 60 years of age, due to the fact that their body is most sensitive to negative phenomena. For people in years, it is recommended to use a single dose of the drug every two days. It is not recommended to use the medication for men who have suffered a stroke and myocardial infarction in the next six months. It is strictly forbidden to take the product for women and adolescents who have not reached the age of majority.

The positive side of Viagra Soft

This drug is an irreplaceable, effective and high quality product. The ecological environment and modern rhythms of life violate the sexual harmony of even the healthiest and strongest men. Generic optimally combines high quality and reasonable price. The main positive point of Viagra Soft is the one hundred percent and high-quality achievement of an erection, as well as the immediate effect of the drug after its use. The action of the drug is carried out in a natural way, directly on sexual urge and arousal. Today, the drug can be purchased without much effort and problems. Viagra Soft can be purchased at the first available pharmacy or in the online store that sells generics and medicines. Online - the store allows you to become the owner of miraculous pills without leaving your home, which allows you to significantly save time and effort. Due to the fact that medicinal substances do not penetrate into the stomach in their original form, but are absorbed into the blood, in the case of its use, you can drink alcoholic beverages in small quantities and eat high-calorie foods. For the rest of drugs similar in effect, this is strongly discouraged. Viagra Soft will be the ideal solution if you are planning a romantic dinner. Having taken it inside, you can eat your favorite food and drink alcoholic beverages without any fear.For 4-6 hours, an erection will have its strength, despite the abundance of absorbed foods and drinks. But a positive result will take place when sexual arousal occurs. Without sexual urge and stimulation, the drug will not work on its own. After the end of intercourse, the male organ takes on a relaxed appearance. And with repeated attraction, a healthy erection will be observed. Taking the drug, a specific hormone appears in the brain of the head that regulates sexual desire. generic Viagra Soft can act on minor causes of a lack of erection. Using the medication, there is no irritation of the inner surface of the stomach. The small pill disappears under the tongue after 15 minutes, at the end of the resorption time, the man may feel a rush of blood to the genital organ. The constant use of Viagra Soft does not reduce the quality of intimacy. The drug has a positive effect on first and second use. After using the pill, the number of sexual relations is determined by the physiological state of the body, therefore it is an individual property of any person. Generic has no effect on reproductive ability, that is, on a man's propensity to conceive a child. It does not have a negative effect on sperm cells and their motility, and will not affect future offspring.

Male potency after taking Viagra Soft

When sexual desire arises, blood rushes to the genital organ to a greater extent than usual. Due to the flow of blood, the penis becomes firm and enlarged in size. The physiological process is called an erection. After the cessation of intercourse, the blood decreases inversely and the erection disappears. If there is a prolonged erection, which is accompanied by more than 6 hours, then you need to consult a doctor. A long lasting erection can negatively affect the genitals. Erectile dysfunction can occur due to the presence of certain ailments, as well as the use of specific medications. For these reasons, blood circulation is insufficient, so an erection cannot occur. In this situation, there is an erectile disorder. During the period of intimacy, the heart begins to function in an increased rhythm, therefore, men with disturbances in the work of the heart should refuse sexual relations. For such problems, immediate and timely treatment is necessary.

If there are sexual dysfunctions, including erectile dysfunction, then you must immediately seek treatment from a specialist. And it is imperative to tackle the treatment of cardiovascular diseases, since the heart must cope with the increased stress during sexual intercourse. It is also imperative to visit a specialist if, with intimacy, painful sensations in the chest area, dizziness and nausea are felt. There is no need to lower the situation to an arbitrary resolution, since ignoring ailments can become a source of a deplorable state of the whole organism. And no medication, no medication can help.

What side effects may appear?

Side effects when using the generic Viagra Soft are much less common than when using the typical Viagra. Most often, men are treated with gastrointestinal upset, migraines and high blood pressure, which is accompanied by rush of blood to the face and neck. Dizziness, allergic intolerance in the form of rashes and redness, as well as nasal congestion may appear in a mild degree. Sometimes taking the drug may be accompanied by a runny nose, impaired clarity of perception of visual objects, painful photosensitivity. If, after taking the medication, a side effect appears, then it is simply necessary to urgently go to the attending doctor. Most men do not focus on redness, migraines and small rashes. Ignoring even the smallest Side effects can cause the development of the disease. You don't need to put your body in danger. If there is an overdose, then you can face a situation where a long-term stable erection does not weaken for 6 hours or more. This phenomenon should alert, and it is better to stop taking the drug indefinitely. To find out the reason for the persistent erection, you need to ask for medical help from a doctor. It should be noted that the generic Viagra Soft will not cure impotence, but only for a certain period of time will cause an erection. Generic is not able to eliminate the existing circulatory disorders of the genital organ.

Does Viagra Soft enhance sexual desire

Viagra Soft can act mainly on a local increase in blood flow to the genital organ, and does not increase sexual desire in the slightest degree.Generic does not induce sexual desire in men and does not have an aphrodisiac effect.

Do I need to consult with experts on the use of the drug

To start using the drug, it is recommended to consult a sex therapist or urologist. You can conduct a comprehensive examination of the body to exclude the presence of contraindications. Contacting a cardiologist and therapist will help make sure that there are no cardiovascular diseases. If there are any ailments with the kidneys, liver, then you should immediately consult an appropriate doctor. It is undesirable to use the medication without consulting a specialist if there are chronic diseases.

Long-term use of the product

During the research and testing of the drug, no baseline data was established that long-term use of tablets can provoke negative effects. The available information at the moment makes it possible to use the remedy, both for a single, as well as for multiple enhancement of an erection.

The effect of the active ingredients of the drug on healthy men

The content of sildenafil in the blood of a person who is in good health can insignificantly accelerate the resumption of an erection after intercourse. There is a period of refractoriness. The recovery stage occurs after each sexual activity and is determined by the absence of an erection for a certain period of time. The tool can also be used by men in years who lead a busy life and have no contraindications to use. But before using the medication, one important point must be taken into account - this is the general condition of the cardiovascular system. If during physical activities (brisk walking, climbing stairs, etc.) you periodically feel ailments in the region of the heart, in this case, you should consult a cardiologist before using the drug.

Distinctive features of Generic Viagra Soft

An improved analogue is a modified and improved analogue of the well-known drug Viagra. Generic is not an aphrodisiac and does not have a hormonal effect. The action of the drug occurs exclusively during the onset of sexual arousal, and is not determined by the desires of a man. Therefore, from the use of this remedy, the appearance of an unplanned erection is completely excluded. The drug activates an erection much faster than the classic version of Viagra. The positive effect begins after about 20-30 minutes. The duration of an erection after using Viagra Soft can reach 4-6 hours. You just need to put one tablet under the tongue and dissolve until thoroughly dissolved. And also the generic goes well with any food and alcoholic beverages. There are no obvious restrictions on the intake of alcohol and your favorite food when using the medication. The possibility of the simultaneous use of the drug, alcohol and high-calorie food is explained by the following processes occurring in the body after the tablet enters the bloodstream. In the sublingual oral cavity there is a huge number of tiny capillaries and receptors located in the immediate vicinity of the mucous membrane of the tongue. Consequently, the microparticles of the drug are quickly picked up by the blood circulation and instantly penetrate the man's body. Thanks to this method of taking the pill, you can not infringe on yourself either in food or in alcoholic beverages.

Instructions for use

Basic Precautions To diagnose negative changes in erectile function, determine their possible sources and choose an effective method of treatment, you need to undergo a thorough examination and physical examination, as well as collect all medical information and history. Sexual activity can pose certain threats in the presence of cardiovascular diseases. Therefore, before proceeding with drug treatment for erectile dysfunction, a specialist should prescribe a comprehensive examination. Medicines that are produced to cure erectile dysfunction should be used with the greatest caution by people with anatomical abnormalities of the reproductive organ. It is necessary to use Viagra Soft with care for men who are prone to the onset of priapism pathology. Medicines that are intended to cure erectile dysfunction are not advisable for men with health problems.

The effectiveness and harmlessness of Viagra Soft

The effectiveness and harmlessness of Viagra Soft in combination with other substances that are created to cure erectile disorders have not been studied or considered. Therefore, in order to avoid unpredictable consequences, it is contraindicated to use such combinations of medicines.Viagra Soft in no way effect on the duration of bleeding, including the use of the drug in combination with aspirin or acetylsalicylic acid. The study of blood cells indicates that its main component - sildenafil increases the anti-aggregation result of nitrogen oxide. Data on the harmlessness of Viagra software for people having diseases that are accompanied by bleeding and exacerbation of ulcers have not been detected. Under such circumstances, the patient with an ulcer of the stomach should use the drug Viagra Soft with maximum precautions. Also, the use of Viagra software should be carried out by precautions to persons who suffer from genetic pigment retinit or genetic impaired functioning of the retina.

Pharmacological features

Generic Viagra Soft is a well-known oral medicine designed to cure erectile disorders. It renews the lost erection and makes it possible to have a response urge to sexual attraction. The somatic erection of the reproductive organ is displayed by the release of oxide nitrogen into the muscle tissues of the elementar body in the case of stimulation and deductions. At the same time, nitrogen oxide activates the enzyme compound of the guanillatcycase, which contributes to the quantitative increase in cyclic guanosine monophosphate, as well as the relaxed state of the muscles tissues and the intensification of the blood flow to the reproductive body. The main component of Sildenafil is a selective and powerful inhibitor of the 5th type of specific phosphodiesterase. Abbreviated name of the substance - FDE5. Sildenafil is responsible for the cleavage of the CGMF in the hollow body of the childbearing organ. Viagra Soft has peripheral action on male erection. Siltenafil substance does not directly have a relaxing effect on the void of the penis, but dynamically increases the atonic effect of oxide nitrogen on muscle tissue. If you activate the CGMF inhibitor, which is manifested in physiological excitation, then the FDE5 decline is generated under the action of sildenafila serves as a source of increase in the level of nitroprusside in the caerz-body of the reproductive organ. The appearance of a favorable pharmacological effect of Viagra software is possible after stimulating the genital organ. With one-time use of the drug Viagra Software in a dosage rate of 25 mg to 100 mg in test healthy people, the means did not provoke clinical deviations in the electrocardiogram. With the limiting decrease in the upper blood pressure in the lying position in the case of receiving the means inside the dosage of 100 mg is approximately 8.4 mm mercury pillars. Accordingly, with a maximum reduction, the lower blood pressure in the lying position is 5.5 mm mercury column. The pressure decreases due to the vasodilant action of sildenafil. This process explains the process with a possible increase in the level of CGMF in the muscular tissue of blood vessels. The drug Viagra Soft worsens the condition of visual acuity and contrast of the perception of organs of vision. Using the testing of Farnsworth-Munsell 100, in some subjects after taking the limiting dose of the drug, instantly scattered disorder was detected in a light form of distinction of a blue-green gamut of shades. After two hours after use, these changes completely disappeared. Disorganization of color view is possible due to the oppression of PDE6, participating in the process of perceiving the light of the retina. Analytical examination in vitro revealed that the effective action of Sildenafil on the 6 Type of PDE is inferior in dynamism and effectiveness 10 times in the ratio of FDE5. The result of the study indicates the activity of sildenafil on PDE5, which exceeds its intensity in thousands of times in relation to the remaining phosphodiesterase isoforms. The effectiveness of sildenafil on type 5 phosphodiesterase overlaps its effectiveness compared to PDE3 4000 times. Phosphodiesterase 3 type contributes to the cuts of the heart muscle.

Clinical Studies Viagra Soft

To study the effectiveness and safety of the drug Viagra Soft, studies were conducted in the form of 21 randomized, placebo controlled, double-blind research. The experiment lasted almost 6 months. During testing, Viagra Soft consumed 3 thousand men who had erectile disorders of various origin, such as organic, psychological and mixed. The age category of the subjects: from 19-year-old guys to 87-year-old men. To determine the effectiveness of the drug on a common basis, a diary was applied, an erection registration, an estimate of the international index of an erectile function, which is a questionnaire for evaluating erection, as well as surveys of the subjects and their partners. The effectiveness of the drug Viagra Software, assessing the ability of the medication to promote the offensive and further conservation of an erection, which would be sufficient to commit intimate proximity, was witnessed in all types of research.The positive effect and the result is preserved and under long-term cure for one year. The tests noted the improvement in the erectile function when using a fixed concentration of the drug in the following progression:

• reception 25 mg of the drug - improvement in 62% of the subjects;
• 50 mg of means - a positive effect of 74% of men;
• 100 mg - positive dynamics in 82% Patients.

When using placebo tablets, only 25% of the subjects reached the erectile function. The results of the experiment showed that the Viagra software is improving not only an erectile function, but also sensations from orgasm, satisfaction from intimate proximity. In studies, the number of men who have diseases - diabetes, noted the positive trend on the use of Viagra software, amounted to 59%. 43% of men who suffered a radical prostatectomy, as well as 83% of the tests of the spinal injury, noted the improvement in the erectile function. When receiving placebo tablets, these data are 16%, 15%, 12%, respectively.

Viagra Soft: Pharmacokinetic properties

The pharmacokinetic properties include the absorption rate of the drug, its distribution, metabolic processes and withdrawal from the body.

Suction

Viagra Soft is absorbed in a short time. The concentration of drugs in the blood from consumption on a non-stomach reaches a maximum action for 20 to 120 minutes, and the average value is 60 minutes. Full biological availability of Viagra software is approximately 41%. The accessibility interval has the following percentages: from 25% to 63%. After using Viagra tablets, 25 mg to 100 mg pharmacokinetics - linear. After using the drug in combination with high-calorie food, the rate of absorption of the active substance is reduced to a slight measure.

Distribution

The volume fraction of the distribution of the fundamental component - siltenafil in a static arrangement is approximately 105 liters, which means its dispersonation in the muscles of the critical organ. The main substance of sildenafil, circulating M-desmetile metabolite, is connected to the blood proteins by 96%. The total concentration of the drug Viagra software does not depend on its links with proteins. In healthy subjects, which were exposed to the study, the concentration of the drug - 0.0002% was determined in seed after 1.5 hours from the use of the means. With a single use of 100 mg, 188 ng was detected.

Metabolism

Siltenafil substance concentrates exclusively under the action of CYP3A4, as the main path and CYP2C9, as an additional, in the microsomal liver isoenbe. Based on the selectivity of the impact on phosphodiesterase, metabolite commensurate with sildenafil substance. Its intensification on the 5 Type of PDE compiles approximately 50% than the intensity of the drug itself. The concentration of the metabolite in the blood is approximately 40% than the concentration in it sildenafil. The substance M-desmeltilmetabolit is undergoing further metabolism. The final semi-exploration period is about 4 hours.

Remove

The removal of sildenafil from human blood is 41 liters per hour. The deadline for half-life is up to 5 hours. Upon the expiration of time from use inward or using intravenous administration, the substance is derived to a greater extent, forming a metabolite (almost 80% dose) with carte masses and in the smallest (less than 20%) with urine.

Generic interaction with other drugs

The combination of various drugs with Viagra software does not affect either affecting the properties of each other.

Effects of drugs on the properties of Viagra software

In vitro experiment, sildenafil metabolism is carried out mainly under the influence of Izoforms in 4, as the main method and 2c9, as a minor method and cytochrome P450. From where it follows that inhibitors of data from the isfeimments can reduce the time of removal of the substance from the body. In the course of the experiment in vivo, it turned out that cimetidine in 800 mg is a non-specific CYP3A4 inhibitor. With its simultaneous use with Viagra, software in healthy subjects, he caused an increase in Sildenafil content by 56%. The population pharmacokinetic study of the clinical outcomes of the study revealed decline to remove sildenafil in combination with CYP3A4 inhibitors in the form of erythromycin, ketoconazole and cimetidine. At the same time, the number of unwanted symptoms of volunteers has not increased. Disposable application of antacid - magnesium or aluminum hydroxide did not affect the bioavailability of Viagra software. After receiving results in a population pharmacokinetic study, CYP2C9 inhibitors in the form of tolbatamide, and warfarin, CYP2D6 - selective inhibitors of serotonin reverse seizure, tricycial antidepressants did not cause changes to Sildenafil properties.

Effects of generic drugs on other medicines

During the In Vitro experiment, it was noticed that the substance sildenafil is a minor inhibitor of isoforms of cytochrome enzymes. At a fixed dose, the blood limit for sildenafil will be approximately 1 μmol. Consequently, Viagra Soft has the ability to influence the period of elimination of metabolites of these isoenzymes to the least extent. In an In Vivo experiment, it was found that there were no significant indicators of combination with 250 mg of tolbutamide or 40 mg of warfarin, which are concentrated in CYP2C9. Viagra Soft in a dosage of 50 mg in combination with aspirins in a dosage of 150 mg is not a source of bleeding.

Viagra Soft with a concentration of 50 mg did not aggravate the hypotensive effect of alcoholic beverages on the subject's body. At a maximum blood alcohol level of approximately 80 mg / dp, the effect of the drug is negligible. For men with arterial hypertension, undesirable symptoms of combining Viagra Soft with amlodipine were not noticed. The accompanying deviation in arterial pressure in the case of a single use of the drug by the subjects in the supine position borders on 8 mm Hg. An analytical review of data on the safety of the drug is characterized by the absence of distinctive features in side effects and effects in men who received simultaneous treatment with Viagra Soft and antihypertensive drugs. Generic Viagra Soft had an enhancing effect on the hypotensive properties of nitrates in single use and with long-term use. Therefore, the simultaneous use of Viagra Soft and nitrates, as well as nitric oxide donors, is strictly prohibited.

Research in Ophthalmology

During the study of the ophthalmic area, a small group of subjects who took Viagra Soft at a concentration of 100 mg with the main component - sildenafil, an hour after use, noted mild impairments in the ability to distinguish between blue-green color shades. After two hours, the manifestations had dissipated. According to pharmacists, this disorder depends on inhibition of type 6 phosphodiesterase. This enzyme is involved in the light processes of the retina. During the experiment, the following was recorded: the substance sildenafil did not have the slightest effect on the perception of contrast, intraocular pressure, the degree of visual acuity, and on the electroretinogram or the diametral size of the pupil of the eye. Using a blind, placebo-controlled experiment, it was found that subjects who consumed the substance sildenafil at a concentration of 100 mg did not show clinically significant deviations in the quality of visual function. The safety and effect of Viagra Soft on the organs of vision have been studied using several types of studies. In particular, a placebo-controlled experiment that lasted six months. The study involved 3 thousand men who are obsessed with disorders in the genital area, namely erectile dysfunction. The age of the subjects starts from 19 years old and ends at 87 years old. All men confirmed that sildenafil is effective, has a positive result and does not impair visual function.

Pharmacokinetic properties of the drug in specific groups of patients

Special groups of sick people mean people of an honorable age, as well as men who have acute renal and hepatic failure.

Older Men

In healthy men over 65 years of age, the elimination of the drug is markedly reduced, and the content of the free substance sildenafil in the blood plasma is almost 40% higher than the level of the substance in the blood of healthy young subjects, the age category of which varies from 19 to 45 years. But in addition to the slower elimination of the drug, analysis of safety data indicates that age differences do not have a direct impact on the number of adverse side effects.

Men with kidney failure

In subjects who suffer from mild kidney disease, the elimination of sildenafil is approximately 50-80 milliliters per minute, and in men with moderate renal insufficiency, the elimination period is 30-49 milliliters per minute. The study was conducted with the use of 50 mg of Viagra Soft, while the pharmacokinetics did not change in any way. In men with acute renal failure, the creatinine elimination period is 30 milliliters per minute. The decrease in the clearance of the substance sildenafil led to an increase in AUC up to 100% and Cmax up to 88%. The findings were compared with men who are age appropriate but who have no renal impairment.

Men with functional liver disorders

In subjects with liver cirrhosis, the elimination period of sildenafil decreased, and therefore the AUC and Cmax values increased to 84% and 47%, respectively. We compared the indices of two groups of subjects of the same age category, but subdivided into a group of healthy men and a group of subjects with abnormalities in the functioning of the liver.

Expiry date and storage conditions of Viagra Soft

Generic Viagra Soft has passed all clinical trials, tested for efficacy and safety. The drug is manufactured in India by the pharmaceutical company CIPLA Ltd. The maximum shelf life from the date of release of the tablets is 2 years. After the expiration date, the drug must be disposed of, as its use can be harmful to health. An expired drug can lead to poisoning. It is necessary to store the drug in a darkened room at a temperature not exceeding + 30C. But the storage temperature should not be less than + 15C, since the destructive effect of cold can make the tablets unusable. Before using the generic Viagra Soft, it is imperative to check the expiration date and shelf life, which is indicated on the package. It is necessary to store the product out of the reach of young children. Moisture, dampness and hot temperatures have a destructive effect on the drug, so you need to carefully monitor where Viagra Soft is stored. It is not recommended to keep the preparation in a sunny place.